Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912395686> ?p ?o ?g. }
- W2912395686 abstract "We aimed to longitudinally assess the relationship between changing brain energy metabolism (glucose and acetoacetate) and cognition during healthy aging. Participants aged 71 ± 5 y underwent cognitive evaluation and quantitative positron emission tomography (PET) and magnetic resonance imaging (MRI) scans at baseline (N=25) and two (N=25) and four (N=16) years later. During the follow-up, the rate constant for brain extraction of glucose (Kglc) declined by 6-12% mainly in the temporo-parietal lobes and cingulate gyri (p ≤ 0.05), whereas acetoacetate extraction and utilization remained unchanged in all brain regions (p ≥ 0.06). Over the four years, cognitive results remained within the normal age range but the main age-related decline was observed in processing speed. Kglc in the caudate was directly related to performance on several cognitive tests (r = +0.41 to +0.43, all p ≤ 0.04). Peripheral insulin resistance assessed by the HOMA-IR was significantly inversely related to Kglc in the thalamus (r = -0.44, p = 0.04) and in the caudate (r = -0.43, p = 0.05), and also inversely related to executive function, attention and processing speed (r = -0.45 to -0.53, all p ≤ 0.03). We confirm in a longitudinal setting that the age-related decline in brain glucose extraction is directly associated with declining performance on some tests of cognition but does not significantly affect brain acetoacetate extraction." @default.
- W2912395686 created "2019-02-21" @default.
- W2912395686 creator A5004394941 @default.
- W2912395686 creator A5004751755 @default.
- W2912395686 creator A5010929089 @default.
- W2912395686 creator A5013694545 @default.
- W2912395686 creator A5017211312 @default.
- W2912395686 creator A5022831027 @default.
- W2912395686 creator A5043056372 @default.
- W2912395686 creator A5049421074 @default.
- W2912395686 creator A5060325739 @default.
- W2912395686 creator A5062439140 @default.
- W2912395686 creator A5071545099 @default.
- W2912395686 creator A5074669775 @default.
- W2912395686 creator A5077466314 @default.
- W2912395686 creator A5084217897 @default.
- W2912395686 creator A5088681787 @default.
- W2912395686 creator A5089103483 @default.
- W2912395686 date "2019-01-15" @default.
- W2912395686 modified "2023-10-18" @default.
- W2912395686 title "Links Between Metabolic and Structural Changes in the Brain of Cognitively Normal Older Adults: A 4-Year Longitudinal Follow-Up" @default.
- W2912395686 cites W1165930182 @default.
- W2912395686 cites W1494937589 @default.
- W2912395686 cites W1602795264 @default.
- W2912395686 cites W1895530546 @default.
- W2912395686 cites W1919119672 @default.
- W2912395686 cites W1926002420 @default.
- W2912395686 cites W1963947389 @default.
- W2912395686 cites W1965609036 @default.
- W2912395686 cites W1968941072 @default.
- W2912395686 cites W1983761458 @default.
- W2912395686 cites W1986144956 @default.
- W2912395686 cites W1988453006 @default.
- W2912395686 cites W1992922736 @default.
- W2912395686 cites W1994694505 @default.
- W2912395686 cites W1997241465 @default.
- W2912395686 cites W1997671274 @default.
- W2912395686 cites W1999434840 @default.
- W2912395686 cites W2009088633 @default.
- W2912395686 cites W2009487160 @default.
- W2912395686 cites W2016771531 @default.
- W2912395686 cites W2025767657 @default.
- W2912395686 cites W2028050242 @default.
- W2912395686 cites W2028942474 @default.
- W2912395686 cites W2034619353 @default.
- W2912395686 cites W2044832776 @default.
- W2912395686 cites W2046547626 @default.
- W2912395686 cites W2050814633 @default.
- W2912395686 cites W2056367893 @default.
- W2912395686 cites W2063555256 @default.
- W2912395686 cites W2065951338 @default.
- W2912395686 cites W2067165730 @default.
- W2912395686 cites W2072418095 @default.
- W2912395686 cites W2072630180 @default.
- W2912395686 cites W2079260434 @default.
- W2912395686 cites W2080848024 @default.
- W2912395686 cites W2086216368 @default.
- W2912395686 cites W2092078486 @default.
- W2912395686 cites W2094735965 @default.
- W2912395686 cites W2100279614 @default.
- W2912395686 cites W2101966650 @default.
- W2912395686 cites W2110065044 @default.
- W2912395686 cites W2111327129 @default.
- W2912395686 cites W2129047299 @default.
- W2912395686 cites W2134825774 @default.
- W2912395686 cites W2138923981 @default.
- W2912395686 cites W2139886607 @default.
- W2912395686 cites W2142712225 @default.
- W2912395686 cites W2143047222 @default.
- W2912395686 cites W2160234571 @default.
- W2912395686 cites W2169096667 @default.
- W2912395686 cites W2182460906 @default.
- W2912395686 cites W2195969592 @default.
- W2912395686 cites W2238829543 @default.
- W2912395686 cites W2460959997 @default.
- W2912395686 cites W2518997301 @default.
- W2912395686 cites W2530329032 @default.
- W2912395686 cites W2583488853 @default.
- W2912395686 cites W2593564498 @default.
- W2912395686 cites W2601577647 @default.
- W2912395686 cites W2604815951 @default.
- W2912395686 cites W2607031541 @default.
- W2912395686 cites W2735557323 @default.
- W2912395686 cites W2788507110 @default.
- W2912395686 cites W4234567378 @default.
- W2912395686 cites W753595173 @default.
- W2912395686 doi "https://doi.org/10.3389/fnagi.2019.00015" @default.
- W2912395686 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6384269" @default.
- W2912395686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30828297" @default.
- W2912395686 hasPublicationYear "2019" @default.
- W2912395686 type Work @default.
- W2912395686 sameAs 2912395686 @default.
- W2912395686 citedByCount "24" @default.
- W2912395686 countsByYear W29123956862019 @default.
- W2912395686 countsByYear W29123956862020 @default.
- W2912395686 countsByYear W29123956862021 @default.
- W2912395686 countsByYear W29123956862022 @default.
- W2912395686 countsByYear W29123956862023 @default.
- W2912395686 crossrefType "journal-article" @default.
- W2912395686 hasAuthorship W2912395686A5004394941 @default.