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• W2912396217 endingPage "1413" @default.
• W2912396217 startingPage "1404" @default.
• W2912396217 abstract "Purpose: Humans are exposed to both natural (e.g. soil, cosmic rays) and human-made radiation sources (e.g. medical devices, nuclear energy production) on a daily basis. The use of medical radiation sources such as Computed Tomography (CT) scans and X-ray has increased rapidly, especially in the treatment of older populations. Micro Ribonucleic Acids (miRNAs) are the major regulators of multiple low-dose radiation-induced biological processes through post-translational inhibition. As a result, understanding age-related changes of miRNA profiles that may compromise the population after low dose radiation exposure has become increasingly important. Materials and methods: In this study, we irradiated both young (2 months) and old (26 months) C57BL/6J mice with low dose radiation (10 mGy and 100 mGy at 1 mGy/min using an open beam 60Co gamma source) and checked the miRNA expression profiles. Results: The global miRNA expression of old mice was significantly reduced compared to that of young mice. Low dose radiation at 10 mGy significantly increased the global miRNA expression in both old and young mice one week following irradiation, which suggests that 10 mGy low dose radiation may reverse the global inhibition effects of aging on miRNA expression. Higher 100 mGy radiation slightly reduced the global expression of miRNAs. We also identified several miRNAs that were elevated or reduced in all of the radiation treatment groups; these can be further explored as candidates for the radiation-induced bio-markers. Conclusions: The results of our study demonstrate that both radiation and aging can influence the global expression of miRNAs, while low dose radiation modulates the expression of miRNAs in a dose-, time-, and age-dependent manner." @default.
• W2912396217 created "2019-02-21" @default.
• W2912396217 creator A5011136464 @default.
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• W2912396217 date "2019-02-15" @default.
• W2912396217 modified "2023-09-28" @default.
• W2912396217 title "Ionizing radiation affects miRNA composition in both young and old mice" @default.
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• W2912396217 doi "https://doi.org/10.1080/09553002.2019.1569771" @default.
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