FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912402463> ?p ?o ?g. }

• W2912402463 abstract "ABSTRACT Dynamic organization of chromatin within the three-dimensional nuclear space has been postulated to regulate gene expression and cell fate. Here, we define the genome-wide distribution of nuclear peripheral heterochromatin as a multipotent P19 cell adopts either a neural or a cardiac fate. We demonstrate that H3K9me2-marked nuclear peripheral heterochromatin undergoes lineage-specific reorganization during cell-fate determination. This is associated with spatial repositioning of genomic loci away from the nuclear periphery as shown by 3D immuno-FISH. Locus repositioning is not always associated with transcriptional changes, but a subset of genes is upregulated. Mef2c is specifically repositioned away from the nuclear periphery during early neurogenic differentiation, but not during early cardiogenic differentiation, with associated transcript upregulation. Myocd is specifically repositioned during early cardiogenic differentiation, but not during early neurogenic differentiation, and is transcriptionally upregulated at later stages of cardiac differentiation. We provide experimental evidence for lineage-specific regulation of nuclear architecture during cell-fate determination in a mouse cell line." @default.
• W2912402463 created "2019-02-21" @default.
• W2912402463 creator A5004404479 @default.
• W2912402463 creator A5024863554 @default.
• W2912402463 creator A5057280899 @default.
• W2912402463 creator A5063761953 @default.
• W2912402463 creator A5070456684 @default.
• W2912402463 creator A5082092297 @default.
• W2912402463 date "2019-02-01" @default.
• W2912402463 modified "2023-10-15" @default.
• W2912402463 title "Lineage-specific reorganization of nuclear peripheral heterochromatin and H3K9me2 domains" @default.
• W2912402463 cites W1826748661 @default.
• W2912402463 cites W1956857062 @default.
• W2912402463 cites W1967738006 @default.
• W2912402463 cites W1971977081 @default.
• W2912402463 cites W1978995496 @default.
• W2912402463 cites W1984340155 @default.
• W2912402463 cites W1989483282 @default.
• W2912402463 cites W1999897712 @default.
• W2912402463 cites W2023186182 @default.
• W2912402463 cites W2027815400 @default.
• W2912402463 cites W2033160626 @default.
• W2912402463 cites W2038774969 @default.
• W2912402463 cites W2051518111 @default.
• W2912402463 cites W2057307695 @default.
• W2912402463 cites W2060355887 @default.
• W2912402463 cites W2068001725 @default.
• W2912402463 cites W2096628719 @default.
• W2912402463 cites W2110065044 @default.
• W2912402463 cites W2110905563 @default.
• W2912402463 cites W2113175417 @default.
• W2912402463 cites W2117289097 @default.
• W2912402463 cites W2123622076 @default.
• W2912402463 cites W2146512944 @default.
• W2912402463 cites W2149670621 @default.
• W2912402463 cites W2158217645 @default.
• W2912402463 cites W2169456326 @default.
• W2912402463 cites W2170314963 @default.
• W2912402463 cites W2174420796 @default.
• W2912402463 cites W2411027615 @default.
• W2912402463 cites W2430846749 @default.
• W2912402463 cites W2584394140 @default.
• W2912402463 cites W2616198309 @default.
• W2912402463 cites W2763478649 @default.
• W2912402463 cites W2794574704 @default.
• W2912402463 doi "https://doi.org/10.1242/dev.174078" @default.
• W2912402463 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6382005" @default.
• W2912402463 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30723106" @default.
• W2912402463 hasPublicationYear "2019" @default.
• W2912402463 type Work @default.
• W2912402463 sameAs 2912402463 @default.
• W2912402463 citedByCount "17" @default.
• W2912402463 countsByYear W29124024632019 @default.
• W2912402463 countsByYear W29124024632020 @default.
• W2912402463 countsByYear W29124024632021 @default.
• W2912402463 countsByYear W29124024632023 @default.
• W2912402463 crossrefType "journal-article" @default.
• W2912402463 hasAuthorship W2912402463A5004404479 @default.
• W2912402463 hasAuthorship W2912402463A5024863554 @default.
• W2912402463 hasAuthorship W2912402463A5057280899 @default.
• W2912402463 hasAuthorship W2912402463A5063761953 @default.
• W2912402463 hasAuthorship W2912402463A5070456684 @default.
• W2912402463 hasAuthorship W2912402463A5082092297 @default.
• W2912402463 hasBestOaLocation W29124024631 @default.
• W2912402463 hasConcept C103435993 @default.
• W2912402463 hasConcept C104317684 @default.
• W2912402463 hasConcept C127561419 @default.
• W2912402463 hasConcept C146291010 @default.
• W2912402463 hasConcept C148738053 @default.
• W2912402463 hasConcept C163952510 @default.
• W2912402463 hasConcept C54355233 @default.
• W2912402463 hasConcept C83640560 @default.
• W2912402463 hasConcept C86339819 @default.
• W2912402463 hasConcept C86803240 @default.
• W2912402463 hasConcept C95444343 @default.
• W2912402463 hasConceptScore W2912402463C103435993 @default.
• W2912402463 hasConceptScore W2912402463C104317684 @default.
• W2912402463 hasConceptScore W2912402463C127561419 @default.
• W2912402463 hasConceptScore W2912402463C146291010 @default.
• W2912402463 hasConceptScore W2912402463C148738053 @default.
• W2912402463 hasConceptScore W2912402463C163952510 @default.
• W2912402463 hasConceptScore W2912402463C54355233 @default.
• W2912402463 hasConceptScore W2912402463C83640560 @default.
• W2912402463 hasConceptScore W2912402463C86339819 @default.
• W2912402463 hasConceptScore W2912402463C86803240 @default.
• W2912402463 hasConceptScore W2912402463C95444343 @default.
• W2912402463 hasFunder F4320306076 @default.
• W2912402463 hasFunder F4320306133 @default.
• W2912402463 hasFunder F4320308573 @default.
• W2912402463 hasFunder F4320332161 @default.
• W2912402463 hasIssue "3" @default.
• W2912402463 hasLocation W29124024631 @default.
• W2912402463 hasLocation W29124024632 @default.
• W2912402463 hasLocation W29124024633 @default.
• W2912402463 hasLocation W29124024634 @default.
• W2912402463 hasOpenAccess W2912402463 @default.
• W2912402463 hasPrimaryLocation W29124024631 @default.
• W2912402463 hasRelatedWork W1980033800 @default.
• W2912402463 hasRelatedWork W2098209017 @default.
• W2912402463 hasRelatedWork W2111295882 @default.

• next