Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912406673> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2912406673 endingPage "319" @default.
- W2912406673 startingPage "315" @default.
- W2912406673 abstract "Dimethyl trisulfide (DMTS) is a natural organic trisulfide that has been patented as a promising antidotal candidate against cyanide (CN). The primary mode of action of DMTS is as a sulfur donor that enables the conversion of CN to thiocyanate. Recently, it was discovered that DMTS is capable of oxidizing hemoglobin (Hb) to methemoglobin (MetHb) in vitro. The goal of these experiments was to measure the extent of DMTS-induced MetHb formation in vivo. In these experiments, intramuscular (IM) injections of formulated DMTS were administered to mice. Following the IM injection, blood was drawn and analyzed for MetHb using a rapid spectrophotometric method. Methemoglobin levels peaked in a dose-dependent manner between 20 and 30 min., and then began dropping. The highest MetHb levels measured for the 50, 100, 200 and 250 mg/kg doses of DMTS were respectively 3.28, 6.12, 9.69, and 10.76% MetHb. These experiments provide the first experimental evidence that IM administered DMTS generates MetHb in vivo and provide additional evidence for the presence of a secondary therapeutic pathway for DMTS - CN scavenging by DMTS-generated MetHb." @default.
- W2912406673 created "2019-02-21" @default.
- W2912406673 creator A5006942014 @default.
- W2912406673 creator A5009909228 @default.
- W2912406673 creator A5079980670 @default.
- W2912406673 date "2018-11-02" @default.
- W2912406673 modified "2023-10-16" @default.
- W2912406673 title "Methemoglobin Forming Effect of Dimethyl Trisulfide in Mice" @default.
- W2912406673 cites W1497890785 @default.
- W2912406673 cites W1579386695 @default.
- W2912406673 cites W2005681064 @default.
- W2912406673 cites W2022746069 @default.
- W2912406673 cites W2028187840 @default.
- W2912406673 cites W2053893327 @default.
- W2912406673 cites W2124544819 @default.
- W2912406673 cites W2153283640 @default.
- W2912406673 cites W2229174157 @default.
- W2912406673 cites W2271438853 @default.
- W2912406673 cites W2288679121 @default.
- W2912406673 cites W2330340784 @default.
- W2912406673 cites W2475134019 @default.
- W2912406673 cites W2560081048 @default.
- W2912406673 cites W2570893668 @default.
- W2912406673 cites W2581812757 @default.
- W2912406673 cites W2737311539 @default.
- W2912406673 cites W2746762366 @default.
- W2912406673 cites W2753119593 @default.
- W2912406673 cites W2774326021 @default.
- W2912406673 cites W3021051226 @default.
- W2912406673 doi "https://doi.org/10.1080/03630269.2018.1553182" @default.
- W2912406673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30747047" @default.
- W2912406673 hasPublicationYear "2018" @default.
- W2912406673 type Work @default.
- W2912406673 sameAs 2912406673 @default.
- W2912406673 citedByCount "2" @default.
- W2912406673 countsByYear W29124066732020 @default.
- W2912406673 countsByYear W29124066732022 @default.
- W2912406673 crossrefType "journal-article" @default.
- W2912406673 hasAuthorship W2912406673A5006942014 @default.
- W2912406673 hasAuthorship W2912406673A5009909228 @default.
- W2912406673 hasAuthorship W2912406673A5079980670 @default.
- W2912406673 hasConcept C150903083 @default.
- W2912406673 hasConcept C178790620 @default.
- W2912406673 hasConcept C185592680 @default.
- W2912406673 hasConcept C207001950 @default.
- W2912406673 hasConcept C26865036 @default.
- W2912406673 hasConcept C2775852224 @default.
- W2912406673 hasConcept C2776294642 @default.
- W2912406673 hasConcept C2777737778 @default.
- W2912406673 hasConcept C2778917026 @default.
- W2912406673 hasConcept C2779598325 @default.
- W2912406673 hasConcept C518881349 @default.
- W2912406673 hasConcept C55493867 @default.
- W2912406673 hasConcept C71924100 @default.
- W2912406673 hasConcept C86803240 @default.
- W2912406673 hasConcept C98274493 @default.
- W2912406673 hasConceptScore W2912406673C150903083 @default.
- W2912406673 hasConceptScore W2912406673C178790620 @default.
- W2912406673 hasConceptScore W2912406673C185592680 @default.
- W2912406673 hasConceptScore W2912406673C207001950 @default.
- W2912406673 hasConceptScore W2912406673C26865036 @default.
- W2912406673 hasConceptScore W2912406673C2775852224 @default.
- W2912406673 hasConceptScore W2912406673C2776294642 @default.
- W2912406673 hasConceptScore W2912406673C2777737778 @default.
- W2912406673 hasConceptScore W2912406673C2778917026 @default.
- W2912406673 hasConceptScore W2912406673C2779598325 @default.
- W2912406673 hasConceptScore W2912406673C518881349 @default.
- W2912406673 hasConceptScore W2912406673C55493867 @default.
- W2912406673 hasConceptScore W2912406673C71924100 @default.
- W2912406673 hasConceptScore W2912406673C86803240 @default.
- W2912406673 hasConceptScore W2912406673C98274493 @default.
- W2912406673 hasIssue "5-6" @default.
- W2912406673 hasLocation W29124066731 @default.
- W2912406673 hasLocation W29124066732 @default.
- W2912406673 hasOpenAccess W2912406673 @default.
- W2912406673 hasPrimaryLocation W29124066731 @default.
- W2912406673 hasRelatedWork W1517982398 @default.
- W2912406673 hasRelatedWork W2062754382 @default.
- W2912406673 hasRelatedWork W2071065880 @default.
- W2912406673 hasRelatedWork W2118746293 @default.
- W2912406673 hasRelatedWork W2560113234 @default.
- W2912406673 hasRelatedWork W2746762366 @default.
- W2912406673 hasRelatedWork W2912406673 @default.
- W2912406673 hasRelatedWork W3034370614 @default.
- W2912406673 hasRelatedWork W3168545565 @default.
- W2912406673 hasRelatedWork W96484744 @default.
- W2912406673 hasVolume "42" @default.
- W2912406673 isParatext "false" @default.
- W2912406673 isRetracted "false" @default.
- W2912406673 magId "2912406673" @default.
- W2912406673 workType "article" @default.