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• W2912421929 endingPage "1091" @default.
• W2912421929 startingPage "1085" @default.
• W2912421929 abstract "Autologous stem cell transplantation (ASCT) is challenged by side effects that may be propagated by chemotherapy-induced mucositis, resulting in bacterial translocation and systemic inflammation. Because gastrointestinal damage appears as an early event in this cascade of reactions, we hypothesized that markers reflecting damage to the intestinal barrier could serve as early predictive markers of toxicity. Glucagon-like peptide-1 (GLP-1), a well-known regulator of blood glucose, has been found to promote intestinal growth and repair in animal studies. We investigated fasting GLP-1 plasma levels in 66 adults undergoing ASCT for lymphoma and multiple myeloma. GLP-1 increased significantly after chemotherapy, reaching peak levels at day +7 post-transplant (median, 8 pmol/L [interquartile range, 4 to 12] before conditioning versus 10 pmol/L [interquartile range, 6 to 17] at day +7; P = .007). The magnitude of the GLP-1 increase was related to the intensity of conditioning. GLP-1 at the day of transplantation (day 0) was positively associated with peak C-reactive protein (CRP) levels (46 mg/L per GLP-1 doubling, P < .001) and increase in days with fever (32% per GLP-1 doubling, P = .0058). Patients with GLP-1 above the median at day 0 had higher CRP levels from days +3 to +10 post-transplant than patients with lower GLP-1 (P ≤ .041) with peak values of 238 versus 129 mg/L, respectively. This study, which represents the first clinical investigation of fasting GLP-1 in relation to high-dose chemotherapy, provides evidence that GLP-1 plays a role in regulation of mucosal defenses. Fasting GLP-1 levels may serve as an early predictor of systemic inflammation and fever in patients receiving high-dose chemotherapy." @default.
• W2912421929 created "2019-02-21" @default.
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• W2912421929 date "2019-06-01" @default.
• W2912421929 modified "2023-09-27" @default.
• W2912421929 title "Glucagon-Like Peptide-1 Is a Marker of Systemic Inflammation in Patients Treated with High-Dose Chemotherapy and Autologous Stem Cell Transplantation" @default.
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• W2912421929 cites W1967516239 @default.
• W2912421929 cites W1975245593 @default.
• W2912421929 cites W1977144451 @default.
• W2912421929 cites W1981505639 @default.
• W2912421929 cites W1981910576 @default.
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• W2912421929 doi "https://doi.org/10.1016/j.bbmt.2019.01.036" @default.
• W2912421929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30731250" @default.
• W2912421929 hasPublicationYear "2019" @default.
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