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- W2912423092 abstract "Long QT syndrome (LQTS) is a congenital cardiac disorder defined by the prolongation of the ventricular action potential and the QT interval of the ECG (electrocardiogram). QT interval prolongation might lead to Torsade des pointes and sudden cardiac death. The voltage-gated potassium channel Kv7.1 co-assembled with the KCNE1 regulatory subunit generates the slow delayed rectifier K+ current (IKs). IKs is one of the most important repolarizing currents of the ventricular action potential (AP). Loss-of-function mutations in Kv7.1 channels and KCNE1 are associated with LQTS (LQT1 and LQT5). Polyunsaturated fatty acids (PUFAs) have been proposed as anti-arrhythmic drugs due to their ability to modulate NaV, CaV and KV channels. Different types of PUFAs, such as ω-3, ω-6 and ω-9, and PUFA analogues, such as N-arachidonoyl taurine (N-AT), have been described as Kv7.1/KCNE1 channel activators and, therefore, could possible function as anti-arrhythmic drugs (especially for LQT1 and LQT5). In order to study the effects of PUFAs, not only on IKs current but also on all currents involved in the generation, maintenance and resolution of the cardiac AP, we have optimized an all-optical electrophysiology system. Human induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs) has been described as a useful drug-testing platform. Indeed, it has been shown that iPS-CMs are sensitive to ion channels inhibitors in terms of cardiac AP modulation. We here use a combination of electrically coupled iPS-CMs monolayers with a high resolution all-optical electrophysiology system for early screening of the anti-arrhythmic properties of diverse PUFAs." @default.
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- W2912423092 date "2019-02-01" @default.
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- W2912423092 title "Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as Early-Screening Platform of Anti-Arrhythmic Effects by Pufas" @default.
- W2912423092 doi "https://doi.org/10.1016/j.bpj.2018.11.575" @default.
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