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- W2912423585 abstract "BACKGROUND: The most common and significant cause for morbidity following emergency appendicectomy is surgical wound infection. There are conflicting reports regarding the optimal duration of antibiotic prophylaxis in uncomplicated acute appendicitis. The efficacy of prolonged prophylactic antibiotic treatment in preventing wound infection for uncomplicated acute appendicitis is poorly defined. OBJECTIVES: A prospective randomized study was carried out to compare the efficacy of single dose pre-operative antibiotics with multiple antibiotic doses in reducing the incidence of postoperative wound infection for patients with uncomplicated acute appendicitis. METHODS: One hundred patients with a diagnosis of uncomplicated acute appendicitis were randomized into two groups. Group 1 received single intravenous dose of 1gm cefotaxime & metronidazole 500mg ½ hour before surgery and group 2 received multiple doses following surgery. Postoperative wound infection was the primary endpoint. RESULTS: The two groups were similar with regard to all aspects. The postoperative wound infection rate was not significantly different among the two groups, 8% in group 1 and 7% group 2 (p =0.959). CONCLUSION: Single-dose pre-operative antibiotics is equally effective to multiple-dose in preventing postoperative wound infection in patients undergoing open appendicectomy for uncomplicated acute appendicitis. However, because of the greater convenience and economic implications, single-dose pre-operative antibiotics is the choice of prophylaxis for uncomplicated acute appendicitis." @default.
- W2912423585 created "2019-02-21" @default.
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- W2912423585 date "2015-04-01" @default.
- W2912423585 modified "2023-09-26" @default.
- W2912423585 title "A clinical study of single dose pre-operative antibiotics Versus multi-dose as prophylaxis in a case of uncomplicated acute appendicitis" @default.
- W2912423585 hasPublicationYear "2015" @default.
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