FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912424879> ?p ?o ?g. }

• W2912424879 endingPage "966" @default.
• W2912424879 startingPage "956" @default.
• W2912424879 abstract "Primary biliary cholangitis (PBC) is an organ-specific, T cell-mediated autoimmune disease which is characterized by the breakdown of self-tolerance to the highly conserved pyruvate dehydrogenase complex, especially the pyruvate dehydrogenase E2 complex (PDC-E2). However, the molecular mechanism of breakdown of self-tolerance is still unclear.A combination of multiplex-PCR and immune repertoire sequencing (IR-seq) was used for a standardized analysis of memory T cell receptor (TCR) β-chain repertoire of PBC patient and healthy volunteers. In vitro induction and expansion of human PDC-E2163-176 (human PDC-E2)-specific T cells and E coli PDC-E231-44/134-147/235-248 (E coli PDC-E2)-specific T cells, and identified the human (and E coli) PDC-E2-specific TCRβ repertoire by IR-seq.Primary biliary cholangitis patients have shorter complementarity-determining region 3s (CDR3s), and higher degree of sequence overlap in the TCRβ repertoire of memory T cell. Moreover, altered insertion patterns and skewed TRBV segment usage were observed in PBC patients. With regard to the pathogenesis, the concentration of E coli was higher in PBC patients' faecal. The frequency of E coli (and human)-specific TCRs was higher in the memory TCRβ repertoire of PBC patients compared with healthy controls. Importantly, the TCRβ repertoire characteristics were almost identical between E coli PDC-E2-related TCRs and human PDC-E2-related TCRs, including the patterns of TRBV usage, CDR3 length and amino acid composition.Our findings comprehensively revealed the TCRβ repertoire characterization of PBC patients, and provided a TCR molecular basis to understand the mechanism of cross-recognition between human PDC-E2 and E coli PDC-E2, and the imbalance of immune tolerance in PBC." @default.
• W2912424879 created "2019-02-21" @default.
• W2912424879 creator A5006948080 @default.
• W2912424879 creator A5029747713 @default.
• W2912424879 creator A5040937372 @default.
• W2912424879 creator A5047695889 @default.
• W2912424879 creator A5050620155 @default.
• W2912424879 creator A5051540248 @default.
• W2912424879 creator A5060010227 @default.
• W2912424879 creator A5084558291 @default.
• W2912424879 creator A5086674033 @default.
• W2912424879 date "2019-02-24" @default.
• W2912424879 modified "2023-10-02" @default.
• W2912424879 title "<scp>TCR</scp> β repertoire of memory T cell reveals potential role for <i>Escherichia coli</i> in the pathogenesis of primary biliary cholangitis" @default.
• W2912424879 cites W161187129 @default.
• W2912424879 cites W1780260732 @default.
• W2912424879 cites W1966337867 @default.
• W2912424879 cites W1969811699 @default.
• W2912424879 cites W1970498805 @default.
• W2912424879 cites W2010234379 @default.
• W2912424879 cites W2025404209 @default.
• W2912424879 cites W2036000865 @default.
• W2912424879 cites W2055420557 @default.
• W2912424879 cites W2059378625 @default.
• W2912424879 cites W2069959734 @default.
• W2912424879 cites W2081395451 @default.
• W2912424879 cites W2083311645 @default.
• W2912424879 cites W2155923274 @default.
• W2912424879 cites W2215746560 @default.
• W2912424879 cites W2252527272 @default.
• W2912424879 cites W2295435170 @default.
• W2912424879 cites W2467278060 @default.
• W2912424879 cites W2567043679 @default.
• W2912424879 cites W2763611883 @default.
• W2912424879 cites W2769821087 @default.
• W2912424879 cites W2770612611 @default.
• W2912424879 cites W2782693033 @default.
• W2912424879 cites W2793408729 @default.
• W2912424879 cites W2802290858 @default.
• W2912424879 cites W4233647119 @default.
• W2912424879 doi "https://doi.org/10.1111/liv.14066" @default.
• W2912424879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30721553" @default.
• W2912424879 hasPublicationYear "2019" @default.
• W2912424879 type Work @default.
• W2912424879 sameAs 2912424879 @default.
• W2912424879 citedByCount "17" @default.
• W2912424879 countsByYear W29124248792019 @default.
• W2912424879 countsByYear W29124248792020 @default.
• W2912424879 countsByYear W29124248792021 @default.
• W2912424879 countsByYear W29124248792022 @default.
• W2912424879 countsByYear W29124248792023 @default.
• W2912424879 crossrefType "journal-article" @default.
• W2912424879 hasAuthorship W2912424879A5006948080 @default.
• W2912424879 hasAuthorship W2912424879A5029747713 @default.
• W2912424879 hasAuthorship W2912424879A5040937372 @default.
• W2912424879 hasAuthorship W2912424879A5047695889 @default.
• W2912424879 hasAuthorship W2912424879A5050620155 @default.
• W2912424879 hasAuthorship W2912424879A5051540248 @default.
• W2912424879 hasAuthorship W2912424879A5060010227 @default.
• W2912424879 hasAuthorship W2912424879A5084558291 @default.
• W2912424879 hasAuthorship W2912424879A5086674033 @default.
• W2912424879 hasConcept C121332964 @default.
• W2912424879 hasConcept C159654299 @default.
• W2912424879 hasConcept C19317047 @default.
• W2912424879 hasConcept C203014093 @default.
• W2912424879 hasConcept C24890656 @default.
• W2912424879 hasConcept C2776090121 @default.
• W2912424879 hasConcept C2778473898 @default.
• W2912424879 hasConcept C36394416 @default.
• W2912424879 hasConcept C85630698 @default.
• W2912424879 hasConcept C86803240 @default.
• W2912424879 hasConcept C8891405 @default.
• W2912424879 hasConceptScore W2912424879C121332964 @default.
• W2912424879 hasConceptScore W2912424879C159654299 @default.
• W2912424879 hasConceptScore W2912424879C19317047 @default.
• W2912424879 hasConceptScore W2912424879C203014093 @default.
• W2912424879 hasConceptScore W2912424879C24890656 @default.
• W2912424879 hasConceptScore W2912424879C2776090121 @default.
• W2912424879 hasConceptScore W2912424879C2778473898 @default.
• W2912424879 hasConceptScore W2912424879C36394416 @default.
• W2912424879 hasConceptScore W2912424879C85630698 @default.
• W2912424879 hasConceptScore W2912424879C86803240 @default.
• W2912424879 hasConceptScore W2912424879C8891405 @default.
• W2912424879 hasFunder F4320321001 @default.
• W2912424879 hasIssue "5" @default.
• W2912424879 hasLocation W29124248791 @default.
• W2912424879 hasLocation W29124248792 @default.
• W2912424879 hasOpenAccess W2912424879 @default.
• W2912424879 hasPrimaryLocation W29124248791 @default.
• W2912424879 hasRelatedWork W1564062834 @default.
• W2912424879 hasRelatedWork W1581000856 @default.
• W2912424879 hasRelatedWork W2002773091 @default.
• W2912424879 hasRelatedWork W2140812930 @default.
• W2912424879 hasRelatedWork W238070723 @default.
• W2912424879 hasRelatedWork W2478044535 @default.
• W2912424879 hasRelatedWork W2481968835 @default.
• W2912424879 hasRelatedWork W2575168929 @default.
• W2912424879 hasRelatedWork W2592570385 @default.

• next