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- W2912431693 abstract "Trauma disrupts the balance of the pro- and anti-inflammatory immune response. The inflammatory response following trauma is dependent on the severity of injury. We hypothesized that trauma evokes a Th-9, Th-22 and T-regulatory type of immune response, which has a central role in the post-trauma immunopathogenesis, tissue healing and the outcome of trauma patients. A cohort of 30 non-referred, polytrauma survivors based on the injury severity score (ISS) and 30 aged-matched healthy controls (18-65 years old) at JPNA Trauma center were studied. Two equal sub-cohorts were defined as Minor (ISS<15) and major (ISS>15) trauma. Whole blood analysis was done using multicolor flow cytometry to study the frequencies of Th-9 (CD4+ IL9+), Th-22 (CD4+IL22+) and T-regulatory (CD4+TGFβ+) cells: within 24 hours (day 0), and day 2, day 5, day 10 of injury & on the day of discharge. The cell frequencies were compared inter-group and with healthy controls. All patients were clinically followed-up till their outcome at the hospital. Following minor trauma, a higher Th-9 (0.08-29.58%; p=0.01) & Th-22 (0.77-5.95%; p=0.03) and T-regulatory (0-1.46%; p <0.001) responses were observed. While, in major trauma patients, a lower Th-9 (0.08-9.08%; p=0.01) and Th-22 (0.62-4.51%; p=0.02), and predominant & consistent T-regulatory (3.80-9.44% p=0.001) cell responses were observed. Minor injuries evoked a higher Th-9 & Th-22 response while severe injuries induced a predominant T regulatory cell response. There was a positive correlation between the frequency of T-regulatory cells and severity of injury." @default.
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- W2912431693 date "2019-02-01" @default.
- W2912431693 modified "2023-09-28" @default.
- W2912431693 title "Dynamics of T helper 9, T helper 22, and regulatory T helper cells in minor & major trauma" @default.
- W2912431693 doi "https://doi.org/10.1016/j.jaci.2018.12.331" @default.
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