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• W2912431762 abstract "The therapeutic potential of adiponectin regulation has received interest because of its association with diverse human disease conditions, such as diabetes, obesity, atherosclerosis, and cancer. Phenylethylchromone derivatives from Aquilaria malaccensis-derived agarwood promoted adiponectin secretion during adipogenesis in human bone marrow mesenchymal stem cells, and 5,6-dihydroxy-2-(2-phenylethyl)chromone (1) was identified as a new chromone derivative. A target identification study with the most potent adiponectin-secretion-promoting phenylethylchromones, 6-methoxy-2-(2-phenylethyl)chromone (3) and 7-methoxy-2-(2-phenylethyl)chromone (4), showed that they are PPARγ partial agonists. Therefore, the diverse therapeutic effects of agarwood are associated with a PPARγ-mediated adiponectin-secretion-promoting mechanism." @default.
• W2912431762 created "2019-02-21" @default.
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• W2912431762 date "2019-01-23" @default.
• W2912431762 modified "2023-10-17" @default.
• W2912431762 title "Adiponectin-Secretion-Promoting Phenylethylchromones from the Agarwood of <i>Aquilaria malaccensis</i>" @default.
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• W2912431762 doi "https://doi.org/10.1021/acs.jnatprod.8b00635" @default.
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