Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912433596> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2912433596 abstract "282 Background: PDAC has a very poor prognosis and around 50% of the patients die within two months of their diagnosis and around 10% live beyond one year. In this study we sought to find biomarkers differentiating patients with early death from those with more prolonged survival. Methods: Tumors from our patients with PDAC were examined using NexGen sequencing (evaluating somatic mutations in 592 genes), immunohistochemistry, and in-situ hybridization (Caris Life Sciences). Tumor mutational burden, microsatellite instability, copy number variation, and gene fusion assessment were done in a subset of samples. Extremes in clinical outcome were defined as death in < 4 months and > 12 months from metastasis diagnosis. Fischer’s exact tests were used to associate the categorical clinical data and genomic factors with the extremes of clinical outcome. A t-test was used to associate the continuous clinical factors with the extreme outcomes. Hierarchical clustering using the Ward amalgamation and binary distance metric was used to define cluster based upon the genomic factors. Results: From October 2014 to August 2018, we evaluated 115 patients. 15 patients with PDAC died < 4 months and 39 died > 12 month from the time of metastasis diagnosis. Compared to the patients with prolonged survival, patients with an early death were significantly older (Average 67.5 vs. 60.5 years old, P = 0.03) and had significantly higher neutrophil counts (average 9.6 vs. 5.1, P = 0.001) and monocyte counts (average 1 vs. 0.6, P = 0.01). No genomic alteration differentiated the groups with extreme outcomes. None of the clusters defined upon the genomic factors differentiated the two outcome groups. Using classification model to predict early death vs prolonged survival, no factor evaluated by the genomic profiling was discriminatory between the groups. Conclusions: We did not find a pattern of genomic alteration difference in PDAC patients between the short-term versus the long-term survivals using Next Generation Sequencing. The short-term survivals were older and had higher neutrophil and monocyte counts at the time of metastatic disease diagnosis." @default.
- W2912433596 created "2019-02-21" @default.
- W2912433596 creator A5013768762 @default.
- W2912433596 creator A5043399313 @default.
- W2912433596 creator A5044781652 @default.
- W2912433596 creator A5053703913 @default.
- W2912433596 creator A5072203753 @default.
- W2912433596 creator A5085956632 @default.
- W2912433596 date "2019-02-01" @default.
- W2912433596 modified "2023-10-18" @default.
- W2912433596 title "Comprehensive genomic profiling in metastatic pancreatic adenocarcinoma, correlation with early death versus prolonged survival." @default.
- W2912433596 doi "https://doi.org/10.1200/jco.2019.37.4_suppl.282" @default.
- W2912433596 hasPublicationYear "2019" @default.
- W2912433596 type Work @default.
- W2912433596 sameAs 2912433596 @default.
- W2912433596 citedByCount "1" @default.
- W2912433596 countsByYear W29124335962022 @default.
- W2912433596 crossrefType "journal-article" @default.
- W2912433596 hasAuthorship W2912433596A5013768762 @default.
- W2912433596 hasAuthorship W2912433596A5043399313 @default.
- W2912433596 hasAuthorship W2912433596A5044781652 @default.
- W2912433596 hasAuthorship W2912433596A5053703913 @default.
- W2912433596 hasAuthorship W2912433596A5072203753 @default.
- W2912433596 hasAuthorship W2912433596A5085956632 @default.
- W2912433596 hasConcept C104317684 @default.
- W2912433596 hasConcept C121608353 @default.
- W2912433596 hasConcept C126322002 @default.
- W2912433596 hasConcept C143998085 @default.
- W2912433596 hasConcept C180754005 @default.
- W2912433596 hasConcept C185592680 @default.
- W2912433596 hasConcept C2779013556 @default.
- W2912433596 hasConcept C2779767149 @default.
- W2912433596 hasConcept C55493867 @default.
- W2912433596 hasConcept C61320498 @default.
- W2912433596 hasConcept C71924100 @default.
- W2912433596 hasConcept C90924648 @default.
- W2912433596 hasConceptScore W2912433596C104317684 @default.
- W2912433596 hasConceptScore W2912433596C121608353 @default.
- W2912433596 hasConceptScore W2912433596C126322002 @default.
- W2912433596 hasConceptScore W2912433596C143998085 @default.
- W2912433596 hasConceptScore W2912433596C180754005 @default.
- W2912433596 hasConceptScore W2912433596C185592680 @default.
- W2912433596 hasConceptScore W2912433596C2779013556 @default.
- W2912433596 hasConceptScore W2912433596C2779767149 @default.
- W2912433596 hasConceptScore W2912433596C55493867 @default.
- W2912433596 hasConceptScore W2912433596C61320498 @default.
- W2912433596 hasConceptScore W2912433596C71924100 @default.
- W2912433596 hasConceptScore W2912433596C90924648 @default.
- W2912433596 hasLocation W29124335961 @default.
- W2912433596 hasOpenAccess W2912433596 @default.
- W2912433596 hasPrimaryLocation W29124335961 @default.
- W2912433596 hasRelatedWork W1993147071 @default.
- W2912433596 hasRelatedWork W2045857417 @default.
- W2912433596 hasRelatedWork W2086207147 @default.
- W2912433596 hasRelatedWork W2423915749 @default.
- W2912433596 hasRelatedWork W2430952171 @default.
- W2912433596 hasRelatedWork W2600950206 @default.
- W2912433596 hasRelatedWork W3206248774 @default.
- W2912433596 hasRelatedWork W3207256650 @default.
- W2912433596 hasRelatedWork W4210295219 @default.
- W2912433596 hasRelatedWork W4286270419 @default.
- W2912433596 isParatext "false" @default.
- W2912433596 isRetracted "false" @default.
- W2912433596 magId "2912433596" @default.
- W2912433596 workType "article" @default.