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- W2912434244 abstract "Mitochondria, known as the energy factories in all cells, are key regulators of multiple vital cellular processes and affect all aspects of mammalian reproduction, being essential for oocyte maturation, fertilization and embryonic development. Mitochondrial dysfunction is consequently implicated in disease as well as age-related infertility. Since mitochondria are inherited exclusively from the mother, the female gamete is central to reproductive outcome and therapeutic interventions, such as mitochondrial replacement therapy (MRT), and development of new diagnostic tools. The primary purpose of MRT is to improve oocyte quality, embryogenesis and fetal development by correcting the imbalance between mutant and wild-type mitochondrial DNA (mtDNA) in the oocyte or zygote, either by replacing mutant mtDNA or supplementing with wild-type counterparts from heterologous or autologous sources. However, the efficacy and safety of these new technologies have not yet been tested in clinical trials, and various concerns exist. Nonetheless, the perspectives for such procedures are intriguing and include two distinct patient populations that could potentially benefit from the clinical implementation of MRT; 1) patients with mtDNA-disease transmission risk; 2) patients undergoing IVF with recurrent poor embryo outcomes due to advanced maternal age. In this review, we outline the intrinsic roles of mitochondria during oogenesis and early embryogenesis in relation to disease and infertility, and discuss the progress in MRT with the developments in reproductive technologies and the related concerns. In addition, we assess the use of mtDNA as a potential biomarker for embryo viability in assisted reproduction." @default.
- W2912434244 created "2019-02-21" @default.
- W2912434244 creator A5000419282 @default.
- W2912434244 creator A5026669838 @default.
- W2912434244 creator A5065732774 @default.
- W2912434244 date "2019-01-01" @default.
- W2912434244 modified "2023-09-28" @default.
- W2912434244 title "Mitochondria and reproduction: possibilities for testing and treatment" @default.
- W2912434244 cites W1521947818 @default.
- W2912434244 cites W1572456387 @default.
- W2912434244 cites W1884068188 @default.
- W2912434244 cites W1960302971 @default.
- W2912434244 cites W1963825171 @default.
- W2912434244 cites W1966276039 @default.
- W2912434244 cites W1967058526 @default.
- W2912434244 cites W1967511612 @default.
- W2912434244 cites W1978460383 @default.
- W2912434244 cites W1982103775 @default.
- W2912434244 cites W1982858056 @default.
- W2912434244 cites W1986945602 @default.
- W2912434244 cites W1988876420 @default.
- W2912434244 cites W2010324884 @default.
- W2912434244 cites W2011116207 @default.
- W2912434244 cites W2011615962 @default.
- W2912434244 cites W2013588487 @default.
- W2912434244 cites W2016179972 @default.
- W2912434244 cites W2022436116 @default.
- W2912434244 cites W2030521264 @default.
- W2912434244 cites W2034809353 @default.
- W2912434244 cites W2039816767 @default.
- W2912434244 cites W2040151712 @default.
- W2912434244 cites W2048931757 @default.
- W2912434244 cites W2050384177 @default.
- W2912434244 cites W2051340142 @default.
- W2912434244 cites W2053829558 @default.
- W2912434244 cites W2055846760 @default.
- W2912434244 cites W2056580543 @default.
- W2912434244 cites W2061167268 @default.
- W2912434244 cites W2062906638 @default.
- W2912434244 cites W2063371306 @default.
- W2912434244 cites W2063664792 @default.
- W2912434244 cites W2063983616 @default.
- W2912434244 cites W2066654520 @default.
- W2912434244 cites W2070392246 @default.
- W2912434244 cites W2075204347 @default.
- W2912434244 cites W2079533090 @default.
- W2912434244 cites W2087034915 @default.
- W2912434244 cites W2091027511 @default.
- W2912434244 cites W2095566500 @default.
- W2912434244 cites W2098405795 @default.
- W2912434244 cites W2098463777 @default.
- W2912434244 cites W2101234364 @default.
- W2912434244 cites W2107206528 @default.
- W2912434244 cites W2107923677 @default.
- W2912434244 cites W2113537324 @default.
- W2912434244 cites W2113615361 @default.
- W2912434244 cites W2113729748 @default.
- W2912434244 cites W2116192451 @default.
- W2912434244 cites W2116957684 @default.
- W2912434244 cites W2118702520 @default.
- W2912434244 cites W2118983368 @default.
- W2912434244 cites W2120440345 @default.
- W2912434244 cites W2123477350 @default.
- W2912434244 cites W2131114829 @default.
- W2912434244 cites W2134728059 @default.
- W2912434244 cites W2136609330 @default.
- W2912434244 cites W2137417617 @default.
- W2912434244 cites W2137770352 @default.
- W2912434244 cites W2142264343 @default.
- W2912434244 cites W2143558309 @default.
- W2912434244 cites W2143698448 @default.
- W2912434244 cites W2147443412 @default.
- W2912434244 cites W2151877403 @default.
- W2912434244 cites W2159467731 @default.
- W2912434244 cites W2162301625 @default.
- W2912434244 cites W2170255248 @default.
- W2912434244 cites W2170550739 @default.
- W2912434244 cites W2196804939 @default.
- W2912434244 cites W2219422939 @default.
- W2912434244 cites W2224398381 @default.
- W2912434244 cites W2240052077 @default.
- W2912434244 cites W2252785585 @default.
- W2912434244 cites W2271112859 @default.
- W2912434244 cites W2310382985 @default.
- W2912434244 cites W2322348567 @default.
- W2912434244 cites W2329563304 @default.
- W2912434244 cites W2338628942 @default.
- W2912434244 cites W2399572771 @default.
- W2912434244 cites W2405239158 @default.
- W2912434244 cites W2407256950 @default.
- W2912434244 cites W2412655997 @default.
- W2912434244 cites W2465231113 @default.
- W2912434244 cites W2470805417 @default.
- W2912434244 cites W2507746105 @default.
- W2912434244 cites W2509808353 @default.
- W2912434244 cites W2514173918 @default.
- W2912434244 cites W2515036978 @default.
- W2912434244 cites W2531962804 @default.
- W2912434244 cites W2532813067 @default.
- W2912434244 cites W2536093898 @default.