FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912441127> ?p ?o ?g. }

• W2912441127 endingPage "1312" @default.
• W2912441127 startingPage "1301" @default.
• W2912441127 abstract "The adjuvanted recombinant zoster vaccine (RZV) has demonstrated >90% efficacy against herpes zoster in adults ≥50 years of age and 68% efficacy in autologous hematopoietic stem cell transplant recipients ≥18 years of age. We report the immunogenicity and safety of RZV administered to patients with solid tumors (STs) before or at the start of a chemotherapy cycle.In this phase 2/3 observer-blind, multicenter study (NCT01798056), patients with STs who were ≥18 years of age were randomized (1:1) to receive 2 doses of RZV or placebo 1-2 months apart and stratified (4:1) according to the timing of the first dose with respect to the start of a chemotherapy cycle (first vaccination 8-30 days before the start or at the start [±1 day] of a chemotherapy cycle). Anti-glycoprotein E (gE) antibody concentrations, gE-specific CD4+ T cell frequencies, and vaccine response rates (VRRs) were assessed 1 month after dose 1 and 1 and 12 months after dose 2. Reactogenicity and safety were assessed in the total vaccinated cohort through 12 months after dose 2.There were 232 participants in the total vaccinated cohort, 185 participants in the according-to-protocol cohort for humoral immunogenicity, and 58 participants in the according-to-protocol cohort for cell-mediated immunogenicity. Postvaccination anti-gE antibody concentrations, gE-specific CD4+ T cell frequencies and VRRs were higher in RZV recipients than in placebo recipients. Solicited adverse events (AEs) were more frequent among RZV recipients than placebo recipients. Incidence of unsolicited AEs, serious AEs, fatalities, and potential immune-mediated diseases were similar between RZV and placebo recipients.RZV was immunogenic in patients with STs receiving immunosuppressive chemotherapies. Humoral and cell-mediated immune responses persisted 1 year after vaccination. No safety concerns were identified." @default.
• W2912441127 created "2019-02-21" @default.
• W2912441127 creator A5003004507 @default.
• W2912441127 creator A5004296895 @default.
• W2912441127 creator A5007727405 @default.
• W2912441127 creator A5017739964 @default.
• W2912441127 creator A5026640055 @default.
• W2912441127 creator A5026944178 @default.
• W2912441127 creator A5030960735 @default.
• W2912441127 creator A5035706765 @default.
• W2912441127 creator A5038614419 @default.
• W2912441127 creator A5039450599 @default.
• W2912441127 creator A5041537315 @default.
• W2912441127 creator A5044901968 @default.
• W2912441127 creator A5046186320 @default.
• W2912441127 creator A5049348377 @default.
• W2912441127 creator A5051915476 @default.
• W2912441127 creator A5051992195 @default.
• W2912441127 creator A5059072073 @default.
• W2912441127 creator A5059940446 @default.
• W2912441127 creator A5066684629 @default.
• W2912441127 creator A5079128178 @default.
• W2912441127 creator A5084123217 @default.
• W2912441127 date "2019-02-01" @default.
• W2912441127 modified "2023-10-18" @default.
• W2912441127 title "Immunogenicity and safety of the adjuvanted recombinant zoster vaccine in patients with solid tumors, vaccinated before or during chemotherapy: A randomized trial" @default.
• W2912441127 cites W1151072144 @default.
• W2912441127 cites W1825495625 @default.
• W2912441127 cites W1965296466 @default.
• W2912441127 cites W1991777712 @default.
• W2912441127 cites W1998244873 @default.
• W2912441127 cites W2010207831 @default.
• W2912441127 cites W2018629351 @default.
• W2912441127 cites W2023366262 @default.
• W2912441127 cites W2033062403 @default.
• W2912441127 cites W2041257537 @default.
• W2912441127 cites W2076982220 @default.
• W2912441127 cites W2085861918 @default.
• W2912441127 cites W2089359789 @default.
• W2912441127 cites W2097885232 @default.
• W2912441127 cites W2105664793 @default.
• W2912441127 cites W2109928588 @default.
• W2912441127 cites W2114213842 @default.
• W2912441127 cites W2118606672 @default.
• W2912441127 cites W2123574813 @default.
• W2912441127 cites W2123910593 @default.
• W2912441127 cites W2126142574 @default.
• W2912441127 cites W2138042091 @default.
• W2912441127 cites W2142549578 @default.
• W2912441127 cites W2173567717 @default.
• W2912441127 cites W2318749007 @default.
• W2912441127 cites W2338472944 @default.
• W2912441127 cites W2519957152 @default.
• W2912441127 cites W2744161197 @default.
• W2912441127 cites W2750039833 @default.
• W2912441127 cites W2784682748 @default.
• W2912441127 cites W2789400684 @default.
• W2912441127 cites W2804416777 @default.
• W2912441127 cites W2804960935 @default.
• W2912441127 cites W3033566150 @default.
• W2912441127 cites W4252677851 @default.
• W2912441127 doi "https://doi.org/10.1002/cncr.31909" @default.
• W2912441127 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6766894" @default.
• W2912441127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30707761" @default.
• W2912441127 hasPublicationYear "2019" @default.
• W2912441127 type Work @default.
• W2912441127 sameAs 2912441127 @default.
• W2912441127 citedByCount "59" @default.
• W2912441127 countsByYear W29124411272019 @default.
• W2912441127 countsByYear W29124411272020 @default.
• W2912441127 countsByYear W29124411272021 @default.
• W2912441127 countsByYear W29124411272022 @default.
• W2912441127 countsByYear W29124411272023 @default.
• W2912441127 crossrefType "journal-article" @default.
• W2912441127 hasAuthorship W2912441127A5003004507 @default.
• W2912441127 hasAuthorship W2912441127A5004296895 @default.
• W2912441127 hasAuthorship W2912441127A5007727405 @default.
• W2912441127 hasAuthorship W2912441127A5017739964 @default.
• W2912441127 hasAuthorship W2912441127A5026640055 @default.
• W2912441127 hasAuthorship W2912441127A5026944178 @default.
• W2912441127 hasAuthorship W2912441127A5030960735 @default.
• W2912441127 hasAuthorship W2912441127A5035706765 @default.
• W2912441127 hasAuthorship W2912441127A5038614419 @default.
• W2912441127 hasAuthorship W2912441127A5039450599 @default.
• W2912441127 hasAuthorship W2912441127A5041537315 @default.
• W2912441127 hasAuthorship W2912441127A5044901968 @default.
• W2912441127 hasAuthorship W2912441127A5046186320 @default.
• W2912441127 hasAuthorship W2912441127A5049348377 @default.
• W2912441127 hasAuthorship W2912441127A5051915476 @default.
• W2912441127 hasAuthorship W2912441127A5051992195 @default.
• W2912441127 hasAuthorship W2912441127A5059072073 @default.
• W2912441127 hasAuthorship W2912441127A5059940446 @default.
• W2912441127 hasAuthorship W2912441127A5066684629 @default.
• W2912441127 hasAuthorship W2912441127A5079128178 @default.
• W2912441127 hasAuthorship W2912441127A5084123217 @default.
• W2912441127 hasBestOaLocation W29124411271 @default.
• W2912441127 hasConcept C126322002 @default.
• W2912441127 hasConcept C142724271 @default.

• next