Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912444205> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2912444205 abstract "In the present study, an Escherichia coli whole cell system with overexpression of a cytochrome P450 oxidase SlgO1 involved in streptolydigin biosynthetic pathway, an E. coli flavodoxin NADP+ oxidoreductase (EcFLDR), and an E. coli flavodoxin A (EcFLDA) were constructed. Biotransformation experiments revealed that SlgO1 can convert tirandamycin C to tirandamycin F, indicating that it can introduce a hydroxyl group into the C-10 position of tirandamycin C. Subsequently, slgO1 was cloned into pSET152AKE vector under the downstream of ermE* promoter, which was, respectively, introduced into Streptomyces sp. SCSIO1666 (tirandamycin B producer), Streptomyces sp. Ju1008 (tirandamycin C producer), and Streptomyces sp. Ju1009 (tirandamycin E producer). A novel tirandamycin derivative tirandamycin L accumulated in the engineered strain Streptomyces sp. Ju1008::slgO1 was isolated and its structure was determined on the basis of nuclear magnetic resonance (NMR) and mass spectrometry. Unlike most of the identified tirandamycins, tirandamycin L possessed a rare C-11–C-12 saturated bond as well as a C-10 ketone moiety. In addition, tirandamycin L showed weaker antibacterial activity. Based on the structure of tirandamycin L, SlgO1 was proposed to be responsible for multiple modifications toward tirandamycin C, including the formation of C-10 hydroxyl and C-11–C-12 saturated bond." @default.
- W2912444205 created "2019-02-21" @default.
- W2912444205 creator A5006924205 @default.
- W2912444205 creator A5024198719 @default.
- W2912444205 creator A5043206163 @default.
- W2912444205 date "2019-02-09" @default.
- W2912444205 modified "2023-10-03" @default.
- W2912444205 title "Cytochrome P450 oxidase SlgO1 catalyzes the biotransformation of tirandamycin C to a new tirandamycin derivative" @default.
- W2912444205 cites W1965144240 @default.
- W2912444205 cites W1976215210 @default.
- W2912444205 cites W1981210730 @default.
- W2912444205 cites W1985152937 @default.
- W2912444205 cites W1993844158 @default.
- W2912444205 cites W2006306186 @default.
- W2912444205 cites W2015271663 @default.
- W2912444205 cites W2021896762 @default.
- W2912444205 cites W2025168003 @default.
- W2912444205 cites W2027406139 @default.
- W2912444205 cites W2050143554 @default.
- W2912444205 cites W2052782654 @default.
- W2912444205 cites W2071157897 @default.
- W2912444205 cites W2104178991 @default.
- W2912444205 cites W2107782429 @default.
- W2912444205 cites W2144292836 @default.
- W2912444205 cites W2311276428 @default.
- W2912444205 cites W2313072180 @default.
- W2912444205 cites W2329269139 @default.
- W2912444205 cites W2330225447 @default.
- W2912444205 cites W2624075007 @default.
- W2912444205 cites W2741590375 @default.
- W2912444205 cites W2742803394 @default.
- W2912444205 cites W2902036401 @default.
- W2912444205 cites W2903039636 @default.
- W2912444205 doi "https://doi.org/10.1007/s13205-019-1611-1" @default.
- W2912444205 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6368906" @default.
- W2912444205 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30800582" @default.
- W2912444205 hasPublicationYear "2019" @default.
- W2912444205 type Work @default.
- W2912444205 sameAs 2912444205 @default.
- W2912444205 citedByCount "2" @default.
- W2912444205 countsByYear W29124442052022 @default.
- W2912444205 crossrefType "journal-article" @default.
- W2912444205 hasAuthorship W2912444205A5006924205 @default.
- W2912444205 hasAuthorship W2912444205A5024198719 @default.
- W2912444205 hasAuthorship W2912444205A5043206163 @default.
- W2912444205 hasBestOaLocation W29124442052 @default.
- W2912444205 hasConcept C104317684 @default.
- W2912444205 hasConcept C107563273 @default.
- W2912444205 hasConcept C134621786 @default.
- W2912444205 hasConcept C181199279 @default.
- W2912444205 hasConcept C185592680 @default.
- W2912444205 hasConcept C2776568683 @default.
- W2912444205 hasConcept C2779920670 @default.
- W2912444205 hasConcept C27881333 @default.
- W2912444205 hasConcept C523546767 @default.
- W2912444205 hasConcept C54355233 @default.
- W2912444205 hasConcept C547475151 @default.
- W2912444205 hasConcept C55493867 @default.
- W2912444205 hasConcept C71240020 @default.
- W2912444205 hasConcept C86803240 @default.
- W2912444205 hasConceptScore W2912444205C104317684 @default.
- W2912444205 hasConceptScore W2912444205C107563273 @default.
- W2912444205 hasConceptScore W2912444205C134621786 @default.
- W2912444205 hasConceptScore W2912444205C181199279 @default.
- W2912444205 hasConceptScore W2912444205C185592680 @default.
- W2912444205 hasConceptScore W2912444205C2776568683 @default.
- W2912444205 hasConceptScore W2912444205C2779920670 @default.
- W2912444205 hasConceptScore W2912444205C27881333 @default.
- W2912444205 hasConceptScore W2912444205C523546767 @default.
- W2912444205 hasConceptScore W2912444205C54355233 @default.
- W2912444205 hasConceptScore W2912444205C547475151 @default.
- W2912444205 hasConceptScore W2912444205C55493867 @default.
- W2912444205 hasConceptScore W2912444205C71240020 @default.
- W2912444205 hasConceptScore W2912444205C86803240 @default.
- W2912444205 hasFunder F4320324174 @default.
- W2912444205 hasIssue "3" @default.
- W2912444205 hasLocation W29124442051 @default.
- W2912444205 hasLocation W29124442052 @default.
- W2912444205 hasLocation W29124442053 @default.
- W2912444205 hasLocation W29124442054 @default.
- W2912444205 hasOpenAccess W2912444205 @default.
- W2912444205 hasPrimaryLocation W29124442051 @default.
- W2912444205 hasRelatedWork W1480924375 @default.
- W2912444205 hasRelatedWork W1995545479 @default.
- W2912444205 hasRelatedWork W2070499973 @default.
- W2912444205 hasRelatedWork W2104656412 @default.
- W2912444205 hasRelatedWork W2117923086 @default.
- W2912444205 hasRelatedWork W2178145641 @default.
- W2912444205 hasRelatedWork W2613344660 @default.
- W2912444205 hasRelatedWork W2902438217 @default.
- W2912444205 hasRelatedWork W2950460872 @default.
- W2912444205 hasRelatedWork W4324307171 @default.
- W2912444205 hasVolume "9" @default.
- W2912444205 isParatext "false" @default.
- W2912444205 isRetracted "false" @default.
- W2912444205 magId "2912444205" @default.
- W2912444205 workType "article" @default.