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• W2912446283 abstract "Introduction: Differentiating pancreatic cystic neoplasms remains a challenge using the current technique of Endoscopic Ultrasound-guided fine needle aspiration (EUS-FNA). Recently, a miniaturized biopsy forceps with an outer diameter of acquire tissue. This through-the-needle forceps biopsy technique (TTNFB) has the potential to increase the diagnostic yield of EUS-FNA for pancreatic cystic neoplasms. The primary aim of this study was to evaluate the technical success and safety of EUS-guided TTNFB for pancreatic cystic lesions. The secondary aim was to evaluate the additive value in diagnostic yield this technique may afford over standard EUS-FNA for pancreatic cystic lesions. Methods: This was a retrospective review of all cases of EUS-guided TTNFB performed for pancreatic cystic lesions at a single academic institution over a 12-month period. Technical success was defined as acquisition of adequate tissue for formal histologic analysis. Safety was assessed through recording peri/post procedural adverse events. EUS-TTN forceps biopsy was performed using the Moray® forceps (US Endoscopy, Mentor, OH) through a standard 19G FNA needle. Biopsy of the cyst wall or septum was performed in each case using the same technique. EUS-FNA of cyst fluid for analysis was performed on each patient when possible. When intraductal papillary mucinous neoplasms (IPMN) was suspected, mucin (MUC) staining was performed to verify the results of the histology and to subtype IPMN. Results: The study included 15 cystic lesions (mean size 26.6mm) in 15 patients. Technical success was 87% (13/15). There was 1 adverse event of intracystic bleeding with no clinical sequelae (6.7%). There were no episodes of pancreatitis. EUS-guided TTNFB with histologic analysis yielded a diagnosis in 11/15 patients (73%) as compared to 0/15 (0%) patients using EUS-FNA and cytologic analysis (p < 0.01). 7 of 8 IPMNs were able to be subtyped based on histologic analysis and MUC staining. Conclusion: This study demonstrates that EUS-TTN forceps biopsy of pancreatic cystic lesions appears safe and can be performed with high technical success. TTN forceps biopsy with histologic analysis demonstrated a significantly higher diagnostic yield for pancreatic cystic lesions compared to EUS-FNA and cytologic analysis. Furthermore, subtyping of IPMN was feasible in this study. EUS-guided through the needle forceps biopsy is a novel technique that should be considered in the diagnostic algorithm for patients with pancreatic cystic lesions." @default.
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• W2912446283 date "2017-10-01" @default.
• W2912446283 modified "2023-10-12" @default.
• W2912446283 title "Endoscopic Ultrasound (EUS)-Guided Through the Needle Forceps Biopsy (TTNFB) of Pancreatic Cystic Lesions Demonstrate Significantly Higher Diagnostic Yield Over Fine Needle Aspiration" @default.
• W2912446283 doi "https://doi.org/10.14309/00000434-201710001-00827" @default.
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