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• W2912448055 endingPage "641" @default.
• W2912448055 startingPage "641" @default.
• W2912448055 abstract "CX3CL1, which is a chemokine involved in many aspects of human pregnancy, is a membrane-bound chemokine shed into circulation as a soluble isoform. Placental CX3CL1 is induced by inflammatory cytokines and is upregulated in severe early-onset preeclampsia. In this study, the hypothesis was addressed whether angiotensin II can deregulate placental CX3CL1 expression, and whether CX3CL1 can promote a pro-inflammatory status of monocytes. qPCR analysis of human placenta samples (n = 45) showed stable expression of CX3CL1 and the angiotensin II receptor AGTR1 throughout the first trimester, but did not show a correlation between both or any influence of maternal age, BMI, and gestational age. Angiotensin II incubation of placental explants transiently deregulated CX3CL1 expression, while the angiotensin II receptor antagonist candesartan reversed this effect. Overexpression of recombinant human CX3CL1 in SGHPL-4 trophoblasts increased adhesion of THP-1 monocytes and significantly increased IL8, CCL19, and CCL13 in co-cultures with human primary monocytes. Incubation of primary monocytes with CX3CL1 and subsequent global transcriptome analysis of CD16⁺ subsets revealed 81 upregulated genes, including clusterin, lipocalin-2, and the leptin receptor. Aldosterone synthase, osteopontin, and cortisone reductase were some of the 66 downregulated genes present. These data suggest that maternal angiotensin II levels influence placental CX3CL1 expression, which, in turn, can affect monocyte to trophoblast adhesion. Release of placental CX3CL1 could promote the pro-inflammatory status of the CD16⁺ subset of maternal monocytes." @default.
• W2912448055 created "2019-02-21" @default.
• W2912448055 creator A5004504299 @default.
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• W2912448055 date "2019-02-02" @default.
• W2912448055 modified "2023-10-15" @default.
• W2912448055 title "Placental CX3CL1 is Deregulated by Angiotensin II and Contributes to a Pro-Inflammatory Trophoblast-Monocyte Interaction" @default.
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• W2912448055 doi "https://doi.org/10.3390/ijms20030641" @default.
• W2912448055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6387455" @default.
• W2912448055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30717334" @default.
• W2912448055 hasPublicationYear "2019" @default.
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