FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912448641> ?p ?o ?g. }

• W2912448641 endingPage "e0210261" @default.
• W2912448641 startingPage "e0210261" @default.
• W2912448641 abstract "Human achaete scute homolog 2 (HASH2) and its murine ortholog MASH2 are potential targets for colorectal cancer immunotherapy. We assessed immunogenicity and antitumor potential of recombinant MASH2 protein combined with AS15 immunostimulant (recMASH2+AS15) in CB6F1 and Apc+/Min-FCCC mice. CB6F1 mice received 4 injections of recMASH2+AS15 or AS15 alone before challenge with TC1-MASH2 tumor cells (Tumor Challenge). Apc+/Min-FCCC mice received 9 injections of recMASH2+AS15 or vehicle (phosphate buffer saline [PBS] or AS15 alone), before (two independent Prophylactic Studies) or after (Immunotherapy) colon adenomas were detectable by colonoscopy. CB6F1 mice immunized with recMASH2+AS15 had a significantly smaller mean tumor size and improved survival rate compared to controls (104 mm2 vs. 197 mm2 [p = 0.009] and 67% vs. 7% [p = 0.001], respectively). In Prophylactic Study 1, the mean number of colon adenomas was significantly lower in Apc+/Min-FCCC mice receiving recMASH2+AS15 compared to PBS (1.8 [95% confidence interval 1.0-3.3] vs. 5.2 [3.7-7.4], p = 0.003). Fewer microadenomas were observed in recMASH2+AS15 groups compared to PBS in both Prophylactic Studies (Study 1: mean 0.4 [0.2-1.0] vs. 1.5 [0.9-2.4], p = 0.009; Study 2: 0.4 [0.2-0.6] vs. 1.1 [0.8-1.5], p = 0.001). In the Immunotherapy Study, fewer colon adenomas tended to be observed in recMASH2+AS15-treated mice (4.1 [2.9-6.0]) compared to controls (AS15 4.7 [3.3-6.6]; PBS 4.9 [3.5-6.9]; no significant difference). recMASH2+AS15 induced MASH2-specific antibody and CD4+ responses in both mouse models. recMASH2+AS15 partially protected mice against MASH2-expressing tumors and reduced spontaneous colorectal adenomas in Apc+/Min-FCCC mice, indicating that MASH2/HASH2 antigens are targets for colorectal cancer immunotherapy." @default.
• W2912448641 created "2019-02-21" @default.
• W2912448641 creator A5000036372 @default.
• W2912448641 creator A5005700148 @default.
• W2912448641 creator A5013052232 @default.
• W2912448641 creator A5017845856 @default.
• W2912448641 creator A5022569332 @default.
• W2912448641 creator A5028466230 @default.
• W2912448641 creator A5038577843 @default.
• W2912448641 creator A5053848761 @default.
• W2912448641 creator A5073010813 @default.
• W2912448641 creator A5082078954 @default.
• W2912448641 creator A5090126068 @default.
• W2912448641 date "2019-01-25" @default.
• W2912448641 modified "2023-09-26" @default.
• W2912448641 title "Self-antigen MASH2 combined with the AS15 immunostimulant induces tumor protection in colorectal cancer mouse models" @default.
• W2912448641 cites W128983294 @default.
• W2912448641 cites W1611653419 @default.
• W2912448641 cites W1807388783 @default.
• W2912448641 cites W1830070533 @default.
• W2912448641 cites W1844867070 @default.
• W2912448641 cites W1966107523 @default.
• W2912448641 cites W1967071065 @default.
• W2912448641 cites W1970343639 @default.
• W2912448641 cites W1976930659 @default.
• W2912448641 cites W1976931615 @default.
• W2912448641 cites W1978665213 @default.
• W2912448641 cites W2001258296 @default.
• W2912448641 cites W2008557163 @default.
• W2912448641 cites W2008667095 @default.
• W2912448641 cites W2011217149 @default.
• W2912448641 cites W2021175628 @default.
• W2912448641 cites W2025594663 @default.
• W2912448641 cites W2046550093 @default.
• W2912448641 cites W2050237800 @default.
• W2912448641 cites W2052874737 @default.
• W2912448641 cites W2066671159 @default.
• W2912448641 cites W2070134936 @default.
• W2912448641 cites W2084662944 @default.
• W2912448641 cites W2093531978 @default.
• W2912448641 cites W2094191556 @default.
• W2912448641 cites W2095692554 @default.
• W2912448641 cites W2102937816 @default.
• W2912448641 cites W2106859466 @default.
• W2912448641 cites W2107053205 @default.
• W2912448641 cites W2107429180 @default.
• W2912448641 cites W2117800515 @default.
• W2912448641 cites W2124749346 @default.
• W2912448641 cites W2127743520 @default.
• W2912448641 cites W2130386024 @default.
• W2912448641 cites W2133899877 @default.
• W2912448641 cites W2138824201 @default.
• W2912448641 cites W2142300779 @default.
• W2912448641 cites W2144803920 @default.
• W2912448641 cites W2146908354 @default.
• W2912448641 cites W2151855631 @default.
• W2912448641 cites W2155507705 @default.
• W2912448641 cites W2155978263 @default.
• W2912448641 cites W2156491299 @default.
• W2912448641 cites W2157824068 @default.
• W2912448641 cites W2168083201 @default.
• W2912448641 cites W2170014636 @default.
• W2912448641 cites W2182583959 @default.
• W2912448641 cites W2255125749 @default.
• W2912448641 cites W2262329766 @default.
• W2912448641 cites W2268148666 @default.
• W2912448641 cites W2346744565 @default.
• W2912448641 cites W2407632247 @default.
• W2912448641 cites W2414038664 @default.
• W2912448641 cites W2518022071 @default.
• W2912448641 cites W2560367415 @default.
• W2912448641 cites W2917837889 @default.
• W2912448641 cites W3117756250 @default.
• W2912448641 cites W75606232 @default.
• W2912448641 doi "https://doi.org/10.1371/journal.pone.0210261" @default.
• W2912448641 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6347180" @default.
• W2912448641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30682058" @default.
• W2912448641 hasPublicationYear "2019" @default.
• W2912448641 type Work @default.
• W2912448641 sameAs 2912448641 @default.
• W2912448641 citedByCount "7" @default.
• W2912448641 countsByYear W29124486412019 @default.
• W2912448641 countsByYear W29124486412020 @default.
• W2912448641 countsByYear W29124486412021 @default.
• W2912448641 countsByYear W29124486412022 @default.
• W2912448641 crossrefType "journal-article" @default.
• W2912448641 hasAuthorship W2912448641A5000036372 @default.
• W2912448641 hasAuthorship W2912448641A5005700148 @default.
• W2912448641 hasAuthorship W2912448641A5013052232 @default.
• W2912448641 hasAuthorship W2912448641A5017845856 @default.
• W2912448641 hasAuthorship W2912448641A5022569332 @default.
• W2912448641 hasAuthorship W2912448641A5028466230 @default.
• W2912448641 hasAuthorship W2912448641A5038577843 @default.
• W2912448641 hasAuthorship W2912448641A5053848761 @default.
• W2912448641 hasAuthorship W2912448641A5073010813 @default.
• W2912448641 hasAuthorship W2912448641A5082078954 @default.
• W2912448641 hasAuthorship W2912448641A5090126068 @default.
• W2912448641 hasBestOaLocation W29124486411 @default.

• next