FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912449840> ?p ?o ?g. }

• W2912449840 abstract "Abstract Circadian rhythm is an autoregulatory rhythm, which is sustained by various mechanisms. The nucleocytoplasmic shuttling of BMAL1 is essential for CLOCK translocation between cytoplasm and nucleus and maintenance of the correct pace of the circadian clock. Here we showed that RAE1 and NUP98 can promote the degradation of BMAL1 and CLOCK. Knockdown of RAE1 and NUP98 suppressed BMAL1 shuttling, leading to cytoplasm accumulation of CLOCK. Furthermore, Chip assay showed that knockdown of RAE1 and NUP98 can enhance the interaction between CLOCK: BMAL1 and E-box region in the promoters of Per2 and Cry1 while reducing its transcription activation activity. Our present study firstly revealed that RAE1 and NUP98 are critical regulators for BMAL1 shuttling." @default.
• W2912449840 created "2019-02-21" @default.
• W2912449840 creator A5002722325 @default.
• W2912449840 creator A5021115462 @default.
• W2912449840 creator A5027456478 @default.
• W2912449840 creator A5030120953 @default.
• W2912449840 creator A5045180153 @default.
• W2912449840 creator A5050650292 @default.
• W2912449840 creator A5060490797 @default.
• W2912449840 creator A5065236570 @default.
• W2912449840 creator A5073739556 @default.
• W2912449840 creator A5074986317 @default.
• W2912449840 creator A5088826526 @default.
• W2912449840 date "2019-01-25" @default.
• W2912449840 modified "2023-10-13" @default.
• W2912449840 title "RAE1 promotes BMAL1 shuttling and regulates degradation and activity of CLOCK: BMAL1 heterodimer" @default.
• W2912449840 cites W1890508363 @default.
• W2912449840 cites W1966928239 @default.
• W2912449840 cites W1972243139 @default.
• W2912449840 cites W1973052124 @default.
• W2912449840 cites W1973788573 @default.
• W2912449840 cites W1974736479 @default.
• W2912449840 cites W1978248876 @default.
• W2912449840 cites W1989011389 @default.
• W2912449840 cites W1993994649 @default.
• W2912449840 cites W1994177513 @default.
• W2912449840 cites W2001334760 @default.
• W2912449840 cites W2003302378 @default.
• W2912449840 cites W2009132775 @default.
• W2912449840 cites W2011052397 @default.
• W2912449840 cites W2016153572 @default.
• W2912449840 cites W2020898077 @default.
• W2912449840 cites W2021026930 @default.
• W2912449840 cites W2035089766 @default.
• W2912449840 cites W2044016151 @default.
• W2912449840 cites W2056902975 @default.
• W2912449840 cites W2061924603 @default.
• W2912449840 cites W2097883984 @default.
• W2912449840 cites W2104290916 @default.
• W2912449840 cites W2132048198 @default.
• W2912449840 cites W2137252071 @default.
• W2912449840 cites W2138968849 @default.
• W2912449840 cites W2142478420 @default.
• W2912449840 cites W2151599212 @default.
• W2912449840 cites W2157481078 @default.
• W2912449840 cites W2164824098 @default.
• W2912449840 cites W2167389860 @default.
• W2912449840 doi "https://doi.org/10.1038/s41419-019-1346-2" @default.
• W2912449840 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6347605" @default.
• W2912449840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30683868" @default.
• W2912449840 hasPublicationYear "2019" @default.
• W2912449840 type Work @default.
• W2912449840 sameAs 2912449840 @default.
• W2912449840 citedByCount "12" @default.
• W2912449840 countsByYear W29124498402021 @default.
• W2912449840 countsByYear W29124498402022 @default.
• W2912449840 countsByYear W29124498402023 @default.
• W2912449840 crossrefType "journal-article" @default.
• W2912449840 hasAuthorship W2912449840A5002722325 @default.
• W2912449840 hasAuthorship W2912449840A5021115462 @default.
• W2912449840 hasAuthorship W2912449840A5027456478 @default.
• W2912449840 hasAuthorship W2912449840A5030120953 @default.
• W2912449840 hasAuthorship W2912449840A5045180153 @default.
• W2912449840 hasAuthorship W2912449840A5050650292 @default.
• W2912449840 hasAuthorship W2912449840A5060490797 @default.
• W2912449840 hasAuthorship W2912449840A5065236570 @default.
• W2912449840 hasAuthorship W2912449840A5073739556 @default.
• W2912449840 hasAuthorship W2912449840A5074986317 @default.
• W2912449840 hasAuthorship W2912449840A5088826526 @default.
• W2912449840 hasBestOaLocation W29124498401 @default.
• W2912449840 hasConcept C104317684 @default.
• W2912449840 hasConcept C121446783 @default.
• W2912449840 hasConcept C169760540 @default.
• W2912449840 hasConcept C173396325 @default.
• W2912449840 hasConcept C184738001 @default.
• W2912449840 hasConcept C190062978 @default.
• W2912449840 hasConcept C2779064383 @default.
• W2912449840 hasConcept C2779317972 @default.
• W2912449840 hasConcept C38606739 @default.
• W2912449840 hasConcept C54355233 @default.
• W2912449840 hasConcept C86803240 @default.
• W2912449840 hasConcept C95444343 @default.
• W2912449840 hasConceptScore W2912449840C104317684 @default.
• W2912449840 hasConceptScore W2912449840C121446783 @default.
• W2912449840 hasConceptScore W2912449840C169760540 @default.
• W2912449840 hasConceptScore W2912449840C173396325 @default.
• W2912449840 hasConceptScore W2912449840C184738001 @default.
• W2912449840 hasConceptScore W2912449840C190062978 @default.
• W2912449840 hasConceptScore W2912449840C2779064383 @default.
• W2912449840 hasConceptScore W2912449840C2779317972 @default.
• W2912449840 hasConceptScore W2912449840C38606739 @default.
• W2912449840 hasConceptScore W2912449840C54355233 @default.
• W2912449840 hasConceptScore W2912449840C86803240 @default.
• W2912449840 hasConceptScore W2912449840C95444343 @default.
• W2912449840 hasFunder F4320321001 @default.
• W2912449840 hasIssue "2" @default.
• W2912449840 hasLocation W29124498401 @default.
• W2912449840 hasLocation W29124498402 @default.
• W2912449840 hasLocation W29124498403 @default.
• W2912449840 hasLocation W29124498404 @default.

• next