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- W2912453375 abstract "Allergic rhinitis (AR) is a common disease in children; the main pharmacotherapy includes antihistamine and intranasal steroid (INS). Patient preference and compliance of treatment are ones of the key factors that contribute to the success of AR treatment. We conducted a cross-sectional questionnaire survey study in 250 children with AR aged between 1-18 years. The primary outcome was to study compliance and preference of treatment. The secondary outcome was to study adverse effects of pharmacotherapy. 238/250 children (95.2%) had persistent AR which 156 (62.4%) were moderate-to-severe and 82 (32.8%) were mild. 114/250 (45.6%) preferred oral antihistamine (OAH), 66/250 (26.4%) preferred INS, and 67/250 (26.7%) preferred both. There was no significant difference in the preference of treatment by disease severity (p = 0.1348). However, significantly higher number of children with moderate to severe AR preferred INS with/without OAH to only OAH (91:64) than those with mild persistent AR (35:45), p-value = 0.0293. The compliance to oral antihistamine (72.8%) was better than INS (64.8%). Adverse symptoms of INS were reported in 65/243 children (26.7%) and 42/250 (16.8%) in OAH. The most reported adverse effect of INS was post nasal dripping (17.3%, 75% in budesonide) where drowsiness was the most common in OAH (8.8%). Interestingly, drowsiness was highly reported in second generation OAH: 33.3% in desloratadine, and 16.7% in loratadine. Most children preferred OAH to INS, however, children with more severe AR preferred INS to OAH monotherapy as the main treatment. Drowsiness is commonly found in OAH even in new generation OAH." @default.
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- W2912453375 date "2019-02-01" @default.
- W2912453375 modified "2023-09-27" @default.
- W2912453375 title "Allergic rhinitis treatment preference, compliance and adherence in Thai children" @default.
- W2912453375 doi "https://doi.org/10.1016/j.jaci.2018.12.854" @default.
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