Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912454567> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2912454567 abstract "Background and Purpose: Rapid and progressive loss of brain elements occurs in the setting of acute ischemic stroke (AIS) due to a large-vessel occlusion (LVO). With time, the amount of brain lost increases. This has been previously quantified to be approximately 1.9 million neurons per minute. Clinically observed phenotypes indicate that large heterogeneity exists in ischemic cell death, in this study we aim to quantify the distribution and range of rate of loss of brain elements. Methods: After Institutional Review Board approval, we performed a retrospective chart review of consecutive anterior circulation AIS due to LVO. Ischemic core volume was measured using automated software processing and time from last known well to imaging was recorded. Using previously published data on brain volume and element counts from morphometry and neuro-stereology studies, we computed rate of loss of brain elements for our real-world LVO stroke patients. Results: Mean ischemic core was 50.4 ml and mean time to imaging from symptoms onset was 8.7 hours. This translated to a mean loss per minute of 2.03 million neurons, 14.8 billion synapses and 12.8 kilometers myelinated fibers. The rate of neuron loss was highly variable, ranging from less than 35,000 to more than 27 million neurons per minute. Conclusions: AIS due to LVO has wide ranging phenotypes of infarct growth. Rate of neuron loss per minute ranges from less than 35,000 to more than 27 million, with a mean and median of 2 million and 0.9 million respectively. These data suggest that time to treatment may be even more critical for a subset of patients while a separate population of patients may continue to benefit from reperfusion therapy, even at late time windows." @default.
- W2912454567 created "2019-02-21" @default.
- W2912454567 creator A5008513987 @default.
- W2912454567 creator A5036218021 @default.
- W2912454567 creator A5049557636 @default.
- W2912454567 creator A5086203650 @default.
- W2912454567 date "2019-02-01" @default.
- W2912454567 modified "2023-09-27" @default.
- W2912454567 title "Abstract WP38: High Variability in Neuronal Loss: Time is Brain, Re-quantified" @default.
- W2912454567 doi "https://doi.org/10.1161/str.50.suppl_1.wp38" @default.
- W2912454567 hasPublicationYear "2019" @default.
- W2912454567 type Work @default.
- W2912454567 sameAs 2912454567 @default.
- W2912454567 citedByCount "1" @default.
- W2912454567 countsByYear W29124545672023 @default.
- W2912454567 crossrefType "journal-article" @default.
- W2912454567 hasAuthorship W2912454567A5008513987 @default.
- W2912454567 hasAuthorship W2912454567A5036218021 @default.
- W2912454567 hasAuthorship W2912454567A5049557636 @default.
- W2912454567 hasAuthorship W2912454567A5086203650 @default.
- W2912454567 hasConcept C126838900 @default.
- W2912454567 hasConcept C127413603 @default.
- W2912454567 hasConcept C142724271 @default.
- W2912454567 hasConcept C143409427 @default.
- W2912454567 hasConcept C164705383 @default.
- W2912454567 hasConcept C2776993930 @default.
- W2912454567 hasConcept C2780645631 @default.
- W2912454567 hasConcept C2989005 @default.
- W2912454567 hasConcept C65835030 @default.
- W2912454567 hasConcept C71924100 @default.
- W2912454567 hasConcept C78519656 @default.
- W2912454567 hasConceptScore W2912454567C126838900 @default.
- W2912454567 hasConceptScore W2912454567C127413603 @default.
- W2912454567 hasConceptScore W2912454567C142724271 @default.
- W2912454567 hasConceptScore W2912454567C143409427 @default.
- W2912454567 hasConceptScore W2912454567C164705383 @default.
- W2912454567 hasConceptScore W2912454567C2776993930 @default.
- W2912454567 hasConceptScore W2912454567C2780645631 @default.
- W2912454567 hasConceptScore W2912454567C2989005 @default.
- W2912454567 hasConceptScore W2912454567C65835030 @default.
- W2912454567 hasConceptScore W2912454567C71924100 @default.
- W2912454567 hasConceptScore W2912454567C78519656 @default.
- W2912454567 hasIssue "Suppl_1" @default.
- W2912454567 hasLocation W29124545671 @default.
- W2912454567 hasOpenAccess W2912454567 @default.
- W2912454567 hasPrimaryLocation W29124545671 @default.
- W2912454567 hasRelatedWork W2011344863 @default.
- W2912454567 hasRelatedWork W2047255003 @default.
- W2912454567 hasRelatedWork W2049567231 @default.
- W2912454567 hasRelatedWork W2071985005 @default.
- W2912454567 hasRelatedWork W2093421464 @default.
- W2912454567 hasRelatedWork W2163064483 @default.
- W2912454567 hasRelatedWork W2272431884 @default.
- W2912454567 hasRelatedWork W2596025211 @default.
- W2912454567 hasRelatedWork W3141700921 @default.
- W2912454567 hasRelatedWork W4236955258 @default.
- W2912454567 hasVolume "50" @default.
- W2912454567 isParatext "false" @default.
- W2912454567 isRetracted "false" @default.
- W2912454567 magId "2912454567" @default.
- W2912454567 workType "article" @default.