FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912454914> ?p ?o ?g. }

• W2912454914 endingPage "7" @default.
• W2912454914 startingPage "1" @default.
• W2912454914 abstract "There is a need for novel drugs for sarcoma treatment. In the present study, to identify inhibitors with potential therapeutic utility in sarcomas, we screened the growth inhibitory effects of 361 inhibitors, including experimental reagents and anti-cancer drugs approved for use in non-sarcoma malignancies and those under clinical trials. The inhibitors were initially tested using 10 osteosarcoma cell lines. The half-maximal inhibitory concentration (IC50) of leptomycin B, actinomycin D, chetomin, and staurosporine was <100 nM in all the cell lines. As the promiscuous effects of staurosporine on kinases make it unsuitable for clinical applications, the other three inhibitors were tested in an additional 15 sarcoma cell lines derived from synovial sarcoma, fibrosarcoma, liposarcoma, rhabdomyosarcoma, malignant peripheral nerve sheath tumor, leiomyosarcoma, and Ewing’s sarcoma. The IC50 of leptomycin B and actinomycin D was <100 nM in all cell lines and that of chetomin was <100 nM in all but three synovial sarcoma cell lines. Although the clinical development of leptomycin B, a chromosomal region maintenance (CRM)1/exportin (XPO)1 inhibitor, was discontinued because of toxicity, a previous clinical trial revealed that other CRM1/XPO1 inhibitors, such as selinexor, have anti-tumor effects in sarcomas. Actinomycin D has proven clinical utility in the treatment of sarcomas. Chetomin disrupts the interaction of hypoxia-inducible factor-1 with the transcriptional coactivator p300 and its clinical utility has not been established in sarcomas. Chetomin exhibited growth inhibitory effects on sarcoma cells with different histological subtypes. Library screening is a powerful approach to detect the potential utility of anti-cancer drugs in sarcoma treatment." @default.
• W2912454914 created "2019-02-21" @default.
• W2912454914 creator A5048403735 @default.
• W2912454914 creator A5058822913 @default.
• W2912454914 date "2019-01-01" @default.
• W2912454914 modified "2023-10-18" @default.
• W2912454914 title "Screening of a growth inhibitor library of sarcoma cell lines to identify potent anti-cancer drugs" @default.
• W2912454914 cites W1801938867 @default.
• W2912454914 cites W1854116296 @default.
• W2912454914 cites W1969528530 @default.
• W2912454914 cites W1974228208 @default.
• W2912454914 cites W1977242675 @default.
• W2912454914 cites W1985395875 @default.
• W2912454914 cites W1988100051 @default.
• W2912454914 cites W1988968354 @default.
• W2912454914 cites W1995145925 @default.
• W2912454914 cites W1996313023 @default.
• W2912454914 cites W2000246857 @default.
• W2912454914 cites W2004363722 @default.
• W2912454914 cites W2039471063 @default.
• W2912454914 cites W2045228408 @default.
• W2912454914 cites W2061292442 @default.
• W2912454914 cites W2062941476 @default.
• W2912454914 cites W2096965934 @default.
• W2912454914 cites W2100772783 @default.
• W2912454914 cites W2101776780 @default.
• W2912454914 cites W2102879385 @default.
• W2912454914 cites W2117839044 @default.
• W2912454914 cites W2124953953 @default.
• W2912454914 cites W2133095691 @default.
• W2912454914 cites W2142834543 @default.
• W2912454914 cites W2175189903 @default.
• W2912454914 cites W2176184837 @default.
• W2912454914 cites W2239395155 @default.
• W2912454914 cites W2290633618 @default.
• W2912454914 cites W2295557285 @default.
• W2912454914 cites W2323598028 @default.
• W2912454914 cites W2342931301 @default.
• W2912454914 cites W2522803584 @default.
• W2912454914 cites W2592815829 @default.
• W2912454914 doi "https://doi.org/10.2198/jelectroph.63.1" @default.
• W2912454914 hasPublicationYear "2019" @default.
• W2912454914 type Work @default.
• W2912454914 sameAs 2912454914 @default.
• W2912454914 citedByCount "2" @default.
• W2912454914 countsByYear W29124549142019 @default.
• W2912454914 countsByYear W29124549142021 @default.
• W2912454914 crossrefType "journal-article" @default.
• W2912454914 hasAuthorship W2912454914A5048403735 @default.
• W2912454914 hasAuthorship W2912454914A5058822913 @default.
• W2912454914 hasBestOaLocation W29124549141 @default.
• W2912454914 hasConcept C121608353 @default.
• W2912454914 hasConcept C142724271 @default.
• W2912454914 hasConcept C184235292 @default.
• W2912454914 hasConcept C2776495794 @default.
• W2912454914 hasConcept C2776910622 @default.
• W2912454914 hasConcept C2777532014 @default.
• W2912454914 hasConcept C2777751087 @default.
• W2912454914 hasConcept C2777760704 @default.
• W2912454914 hasConcept C2778256501 @default.
• W2912454914 hasConcept C2779084600 @default.
• W2912454914 hasConcept C3020616263 @default.
• W2912454914 hasConcept C502942594 @default.
• W2912454914 hasConcept C54355233 @default.
• W2912454914 hasConcept C55493867 @default.
• W2912454914 hasConcept C71924100 @default.
• W2912454914 hasConcept C81885089 @default.
• W2912454914 hasConcept C86803240 @default.
• W2912454914 hasConcept C97029542 @default.
• W2912454914 hasConceptScore W2912454914C121608353 @default.
• W2912454914 hasConceptScore W2912454914C142724271 @default.
• W2912454914 hasConceptScore W2912454914C184235292 @default.
• W2912454914 hasConceptScore W2912454914C2776495794 @default.
• W2912454914 hasConceptScore W2912454914C2776910622 @default.
• W2912454914 hasConceptScore W2912454914C2777532014 @default.
• W2912454914 hasConceptScore W2912454914C2777751087 @default.
• W2912454914 hasConceptScore W2912454914C2777760704 @default.
• W2912454914 hasConceptScore W2912454914C2778256501 @default.
• W2912454914 hasConceptScore W2912454914C2779084600 @default.
• W2912454914 hasConceptScore W2912454914C3020616263 @default.
• W2912454914 hasConceptScore W2912454914C502942594 @default.
• W2912454914 hasConceptScore W2912454914C54355233 @default.
• W2912454914 hasConceptScore W2912454914C55493867 @default.
• W2912454914 hasConceptScore W2912454914C71924100 @default.
• W2912454914 hasConceptScore W2912454914C81885089 @default.
• W2912454914 hasConceptScore W2912454914C86803240 @default.
• W2912454914 hasConceptScore W2912454914C97029542 @default.
• W2912454914 hasIssue "1" @default.
• W2912454914 hasLocation W29124549141 @default.
• W2912454914 hasOpenAccess W2912454914 @default.
• W2912454914 hasPrimaryLocation W29124549141 @default.
• W2912454914 hasRelatedWork W2030157167 @default.
• W2912454914 hasRelatedWork W2142630616 @default.
• W2912454914 hasRelatedWork W2318279699 @default.
• W2912454914 hasRelatedWork W2321663139 @default.
• W2912454914 hasRelatedWork W2528782336 @default.
• W2912454914 hasRelatedWork W2792030293 @default.
• W2912454914 hasRelatedWork W3031562210 @default.

• next