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- W2912456393 abstract "Melanoma is an aggressive malignancy originating from pigment-producing melanocytes. The development of targeted therapies (MAPK pathway inhibitors) and immunotherapies (immune checkpoint inhibitors) led to a substantial improvement in overall survival of patients. However, the long-term efficacy of such treatments is limited by side effects, lack of clinical effects and the rapidly emerging resistance to treatment. A number of molecular mechanisms underlying this resistant phenotype have already been elucidated. In this review, we summarise currently available treatment options for metastatic melanoma and the known resistance mechanisms to targeted therapies. A focus will be placed on phenotype switching as a mechanism and driver of drug resistance, together with an overview of novel approaches to circumvent resistance. A large body of recent data and literature suggests that tumour progression and phenotype switching could be better controlled and development of resistance prevented or at least delayed, by combining drugs targeting fast- and slow-proliferating cells." @default.
- W2912456393 created "2019-02-21" @default.
- W2912456393 creator A5020175101 @default.
- W2912456393 creator A5020951168 @default.
- W2912456393 creator A5022817338 @default.
- W2912456393 creator A5043955471 @default.
- W2912456393 creator A5072501227 @default.
- W2912456393 date "2019-04-01" @default.
- W2912456393 modified "2023-09-29" @default.
- W2912456393 title "Many ways to resistance: How melanoma cells evade targeted therapies" @default.
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