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- W2912456746 abstract "Purpose: Patients with C and IBS can present with a wide range of functional gastrointestinal disorder (FGID) comorbidities. However, it is unknown how often these comorbidities occur or their temporal relationship to C and IBS. Few studies have differentiated the occurrence of FGID comorbidities before and after diagnoses of C and IBS. Objective: To evaluate the prevalence and costs of FGID comorbidities in a large sample of patients in the 6 months before and after diagnoses (DXs) of C and IBS+C (co-occuring DXs of IBS and C). Methods: A restrospective analysis was performed in an employer database of greater than 500,000 employees. Patient cohorts with C (ICD9s 564.0, 564.00, 564.01, and 564.09), IBS+C (ICD9 564.1× and co-occurring C) and a Control group (neither C nor IBS+C) were identified. For each IBS+C patient identified, 5 C patients and 180 Control patients were matched using logistic regression and propensity scores for age, job tenure, gender, marital status, race, exempt- and full-time employment status, salary, region, Charlson Comorbidity Index Score, and the existence of medical claims. Prevalence and costs for FGID co-morbidities were calculated for the 6 months before and after C and IBS+C DXs by FGID ICD9 code (see figure). Comorbidity comparisons were performed within (before vs after) and between (C vs IBS-C vs control) groups. Prevalence comparisons used z-scores of log odds ratios (Woolf method) and costs were compared by Sattherthwaite t-tests. Results: Data were available for 309 IBS-C patients, 1545 C patients, and 55,620 matched Controls. All cohorts averaged 41 years of age and 74% were female. The prevalence and costs of FGID comorbidities within and between C, IBS-C, and Control groups generally increased. Many findings were significant (see figure).[figure1]FigureConclusion: The prevalence and costs of FGID comorbidities increase after diagnoses of C and IBS+C. Prevalence and costs of comorbidities were similar between C and IBS+C cohorts." @default.
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- W2912456746 date "2007-09-01" @default.
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- W2912456746 title "Functional Gastrointestinal Disorder Comorbidities: Comparisons of Prevalence and Costs in the 6 Months before and after Diagnoses of Constipation (C) and Irritable Bowel Syndrome and Constipation (IBS+C)" @default.
- W2912456746 doi "https://doi.org/10.14309/00000434-200709002-01069" @default.
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