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- W2912457922 abstract "Bacteriophages are the most abundant members of the microbiota and have the potential to shape gut bacterial communities. Changes to bacteriophage composition are associated with disease, but how phages impact mammalian health remains unclear. We noted an induction of host immunity when experimentally treating bacterially driven cancer, leading us to test whether bacteriophages alter immune responses. Treating germ-free mice with bacteriophages leads to immune cell expansion in the gut. Lactobacillus, Escherichia, and Bacteroides bacteriophages and phage DNA stimulated IFN-γ via the nucleotide-sensing receptor TLR9. The resultant immune responses were both phage and bacteria specific. Additionally, increasing bacteriophage levels exacerbated colitis via TLR9 and IFN-γ. Similarly, ulcerative colitis (UC) patients responsive to fecal microbiota transplantation (FMT) have reduced phages compared to non-responders, and mucosal IFN-γ positively correlates with bacteriophage levels. Bacteriophages from active UC patients induced more IFN-γ compared to healthy individuals. Collectively, these results indicate that bacteriophages can alter mucosal immunity to impact mammalian health." @default.
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- W2912457922 date "2019-02-01" @default.
- W2912457922 modified "2023-10-15" @default.
- W2912457922 title "Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis" @default.
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- W2912457922 cites W1963252475 @default.
- W2912457922 cites W1964319062 @default.
- W2912457922 cites W1967239919 @default.
- W2912457922 cites W1971264284 @default.
- W2912457922 cites W1978116622 @default.
- W2912457922 cites W1979217507 @default.
- W2912457922 cites W1992141349 @default.
- W2912457922 cites W1993670827 @default.
- W2912457922 cites W1998505107 @default.
- W2912457922 cites W2002516891 @default.
- W2912457922 cites W2004312418 @default.
- W2912457922 cites W2006292369 @default.
- W2912457922 cites W2008208318 @default.
- W2912457922 cites W2008733625 @default.
- W2912457922 cites W2011297553 @default.
- W2912457922 cites W2013067182 @default.
- W2912457922 cites W2015035889 @default.
- W2912457922 cites W2022995930 @default.
- W2912457922 cites W2034400607 @default.
- W2912457922 cites W2050480541 @default.
- W2912457922 cites W2069296495 @default.
- W2912457922 cites W2072417345 @default.
- W2912457922 cites W2077553363 @default.
- W2912457922 cites W2078754045 @default.
- W2912457922 cites W2078823298 @default.
- W2912457922 cites W2081319466 @default.
- W2912457922 cites W2082860967 @default.
- W2912457922 cites W2083324588 @default.
- W2912457922 cites W2085284704 @default.
- W2912457922 cites W2089030537 @default.
- W2912457922 cites W2089643849 @default.
- W2912457922 cites W2090562908 @default.
- W2912457922 cites W2090711753 @default.
- W2912457922 cites W2092591554 @default.
- W2912457922 cites W2093086300 @default.
- W2912457922 cites W2096139589 @default.
- W2912457922 cites W2097747132 @default.
- W2912457922 cites W2097875133 @default.
- W2912457922 cites W2103561589 @default.
- W2912457922 cites W2117840807 @default.
- W2912457922 cites W2124937554 @default.
- W2912457922 cites W2150968312 @default.
- W2912457922 cites W2151813467 @default.
- W2912457922 cites W2151934830 @default.
- W2912457922 cites W2161251845 @default.
- W2912457922 cites W2165891191 @default.
- W2912457922 cites W2193038643 @default.
- W2912457922 cites W2260815707 @default.
- W2912457922 cites W2314144664 @default.
- W2912457922 cites W2343758687 @default.
- W2912457922 cites W2496221212 @default.
- W2912457922 cites W2593928562 @default.
- W2912457922 cites W2603415762 @default.
- W2912457922 cites W2610035002 @default.
- W2912457922 cites W2735330212 @default.
- W2912457922 cites W2739268225 @default.
- W2912457922 cites W2743296461 @default.
- W2912457922 cites W2769152635 @default.
- W2912457922 cites W2786541232 @default.
- W2912457922 cites W2883885053 @default.
- W2912457922 cites W2886502825 @default.
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- W2912457922 doi "https://doi.org/10.1016/j.chom.2019.01.008" @default.
- W2912457922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6885004" @default.
- W2912457922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30763538" @default.
- W2912457922 hasPublicationYear "2019" @default.
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