Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912459905> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2912459905 endingPage "376" @default.
- W2912459905 startingPage "366" @default.
- W2912459905 abstract "The stratified Cox model is commonly used for stratified clinical trials with time‐to‐event endpoints. The estimated log hazard ratio is approximately a weighted average of corresponding stratum‐specific Cox model estimates using inverse‐variance weights; the latter are optimal only under the (often implausible) assumption of a constant hazard ratio across strata. Focusing on trials with limited sample sizes (50‐200 subjects per treatment), we propose an alternative approach in which stratum‐specific estimates are obtained using a refined generalized logrank (RGLR) approach and then combined using either sample size or minimum risk weights for overall inference. Our proposal extends the work of Mehrotra et al, to incorporate the RGLR statistic, which outperforms the Cox model in the setting of proportional hazards and small samples. This work also entails development of a remarkably accurate plug‐in formula for the variance of RGLR‐based estimated log hazard ratios. We demonstrate using simulations that our proposed two‐step RGLR analysis delivers notably better results through smaller estimation bias and mean squared error and larger power than the stratified Cox model analysis when there is a treatment‐by‐stratum interaction, with similar performance when there is no interaction. Additionally, our method controls the type I error rate while the stratified Cox model does not in small samples. We illustrate our method using data from a clinical trial comparing two treatments for colon cancer." @default.
- W2912459905 created "2019-02-21" @default.
- W2912459905 creator A5013578540 @default.
- W2912459905 creator A5020047598 @default.
- W2912459905 creator A5021935717 @default.
- W2912459905 date "2019-01-31" @default.
- W2912459905 modified "2023-10-12" @default.
- W2912459905 title "Hazard ratio inference in stratified clinical trials with time‐to‐event endpoints and limited sample size" @default.
- W2912459905 cites W1963655127 @default.
- W2912459905 cites W1986705681 @default.
- W2912459905 cites W2035655846 @default.
- W2912459905 cites W2065787672 @default.
- W2912459905 cites W2125296802 @default.
- W2912459905 cites W2139058091 @default.
- W2912459905 cites W2155571712 @default.
- W2912459905 cites W2342633119 @default.
- W2912459905 cites W2593923038 @default.
- W2912459905 cites W2755827943 @default.
- W2912459905 doi "https://doi.org/10.1002/pst.1928" @default.
- W2912459905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30706642" @default.
- W2912459905 hasPublicationYear "2019" @default.
- W2912459905 type Work @default.
- W2912459905 sameAs 2912459905 @default.
- W2912459905 citedByCount "1" @default.
- W2912459905 countsByYear W29124599052023 @default.
- W2912459905 crossrefType "journal-article" @default.
- W2912459905 hasAuthorship W2912459905A5013578540 @default.
- W2912459905 hasAuthorship W2912459905A5020047598 @default.
- W2912459905 hasAuthorship W2912459905A5021935717 @default.
- W2912459905 hasConcept C105795698 @default.
- W2912459905 hasConcept C129848803 @default.
- W2912459905 hasConcept C149782125 @default.
- W2912459905 hasConcept C154945302 @default.
- W2912459905 hasConcept C207103383 @default.
- W2912459905 hasConcept C2776214188 @default.
- W2912459905 hasConcept C33923547 @default.
- W2912459905 hasConcept C41008148 @default.
- W2912459905 hasConcept C44249647 @default.
- W2912459905 hasConcept C50382708 @default.
- W2912459905 hasConcept C66339696 @default.
- W2912459905 hasConceptScore W2912459905C105795698 @default.
- W2912459905 hasConceptScore W2912459905C129848803 @default.
- W2912459905 hasConceptScore W2912459905C149782125 @default.
- W2912459905 hasConceptScore W2912459905C154945302 @default.
- W2912459905 hasConceptScore W2912459905C207103383 @default.
- W2912459905 hasConceptScore W2912459905C2776214188 @default.
- W2912459905 hasConceptScore W2912459905C33923547 @default.
- W2912459905 hasConceptScore W2912459905C41008148 @default.
- W2912459905 hasConceptScore W2912459905C44249647 @default.
- W2912459905 hasConceptScore W2912459905C50382708 @default.
- W2912459905 hasConceptScore W2912459905C66339696 @default.
- W2912459905 hasIssue "3" @default.
- W2912459905 hasLocation W29124599051 @default.
- W2912459905 hasLocation W29124599052 @default.
- W2912459905 hasOpenAccess W2912459905 @default.
- W2912459905 hasPrimaryLocation W29124599051 @default.
- W2912459905 hasRelatedWork W1968524627 @default.
- W2912459905 hasRelatedWork W2052183107 @default.
- W2912459905 hasRelatedWork W2142613554 @default.
- W2912459905 hasRelatedWork W2214928730 @default.
- W2912459905 hasRelatedWork W2360780628 @default.
- W2912459905 hasRelatedWork W2994686985 @default.
- W2912459905 hasRelatedWork W3136232645 @default.
- W2912459905 hasRelatedWork W4225121065 @default.
- W2912459905 hasRelatedWork W4281722959 @default.
- W2912459905 hasRelatedWork W4379796428 @default.
- W2912459905 hasVolume "18" @default.
- W2912459905 isParatext "false" @default.
- W2912459905 isRetracted "false" @default.
- W2912459905 magId "2912459905" @default.
- W2912459905 workType "article" @default.