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- W2912471183 startingPage "28" @default.
- W2912471183 abstract "Pancreatic ductal adenocarcinoma (PDAC) and extrahepatic biliary tract cancer (BTC) are among the malignancies with the highest morbidity and mortality. Despite increasing knowledge on biology and novel therapies, outcome remains poor in these patients. Recent progress in immunotherapies created new hopes in the treatment of PDAC and extrahepatic BTC. Several trials tested immunotherapies in various therapeutic situations as monotherapies or in combinations. Although responses were seen in some of the trials, the value of immunotherapy in PDAC and extrahepatic BTC remains unclear in the current situation, especially regarding the complex biological characteristics with a high stroma component, intrinsic resistance mechanisms and an immunosuppressive, hypoxic microenvironment. These major hurdles have to be taken into account and overcome if immunotherapies should be successful in these tumor entities. Thereby, combinational approaches that allow on the one hand targeted therapy and on the other restore or boost the function of immune cells are promising." @default.
- W2912471183 created "2019-02-21" @default.
- W2912471183 creator A5034891779 @default.
- W2912471183 creator A5069481844 @default.
- W2912471183 creator A5090270623 @default.
- W2912471183 date "2019-01-01" @default.
- W2912471183 modified "2023-10-17" @default.
- W2912471183 title "Immunotherapy: Pancreatic Cancer and Extrahepatic Biliary Tract Cancer" @default.
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