Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912471813> ?p ?o ?g. }
- W2912471813 endingPage "1009" @default.
- W2912471813 startingPage "998" @default.
- W2912471813 abstract "Amylin and amyloid‐β (Aβ) were found to induce reactive oxygen species (ROS) and reactive nitrogen species (RNS) in rat pancreatic β‐cell line, INS‐1 cells, leading to cell death. In this study, we report on reciprocal relationship between the expression of estrogen receptors (ERs) α and β (ERα and ERβ) and generation of ROS/RNS in amylin/Aβ 1–42 ‐treated INS‐1 cells. That is, pharmacological activation of ERs in INS‐1 cells significantly decreases ROS/RNS generation, but blockage of ERs increases ROS/RNS generation. Silibinin is a natural polyphenolic flavonoid isolated from milk thistle with phytoestrogen activities, also known as silybin. Treatment with silibinin down‐regulated ROS/RNS production induced by treatment with amylin/Aβ 1–42 in the cells. Silencing ERs expression with siRNAs targeting ERs showed that the protective effect of silibinin was markedly weakened, indicating that silibinin protection is largely attributed to activation of ERs' signaling. The binding of silibinin to ERs implies that the protective effect of silibinin on amylin/Aβ 1–42 ‐treated INS‐1 cells owes to down‐regulation of ROS/RNS through the activation of ERs phosphorylation. Amylin and Aβ 1–42 cotreatment enhanced furthermore ROS/RNS generation and cytotoxicity through further down‐regulation of ERs phosphorylation, and this was reversed by silibinin. Silibinin also protects INS‐1 cells from amylin and Aβ 1–42 cotreatment. These results indicate that protective effect of silibinin is mediated by enhancement of ERs phosphorylation that depresses ROS/RNS generation in amylin/Aβ 1–42 ‐treated INS‐1 cells." @default.
- W2912471813 created "2019-02-21" @default.
- W2912471813 creator A5003667513 @default.
- W2912471813 creator A5015129046 @default.
- W2912471813 creator A5022644338 @default.
- W2912471813 creator A5026283201 @default.
- W2912471813 creator A5045272575 @default.
- W2912471813 creator A5050205808 @default.
- W2912471813 creator A5062073110 @default.
- W2912471813 creator A5069771785 @default.
- W2912471813 creator A5079036030 @default.
- W2912471813 creator A5091089849 @default.
- W2912471813 date "2019-02-06" @default.
- W2912471813 modified "2023-09-28" @default.
- W2912471813 title "Silibinin protects rat pancreatic β‐cell through up‐regulation of estrogen receptors' signaling against amylin‐ or Aβ<sub>1–42</sub>‐induced reactive oxygen species/reactive nitrogen species generation" @default.
- W2912471813 cites W1552916016 @default.
- W2912471813 cites W1566219902 @default.
- W2912471813 cites W1593001894 @default.
- W2912471813 cites W1607019633 @default.
- W2912471813 cites W1764308599 @default.
- W2912471813 cites W1881405123 @default.
- W2912471813 cites W1974508845 @default.
- W2912471813 cites W1981917874 @default.
- W2912471813 cites W1983282855 @default.
- W2912471813 cites W1983829653 @default.
- W2912471813 cites W1986452732 @default.
- W2912471813 cites W1990826782 @default.
- W2912471813 cites W1996946131 @default.
- W2912471813 cites W1999010280 @default.
- W2912471813 cites W2005077894 @default.
- W2912471813 cites W2024231537 @default.
- W2912471813 cites W2033997062 @default.
- W2912471813 cites W2050178835 @default.
- W2912471813 cites W2054636900 @default.
- W2912471813 cites W2055311718 @default.
- W2912471813 cites W2056140583 @default.
- W2912471813 cites W2056410662 @default.
- W2912471813 cites W2059467226 @default.
- W2912471813 cites W2061551473 @default.
- W2912471813 cites W2062542032 @default.
- W2912471813 cites W2068688814 @default.
- W2912471813 cites W2070719504 @default.
- W2912471813 cites W2072787342 @default.
- W2912471813 cites W2083990676 @default.
- W2912471813 cites W2095960040 @default.
- W2912471813 cites W2099215442 @default.
- W2912471813 cites W2107742907 @default.
- W2912471813 cites W2115150362 @default.
- W2912471813 cites W2119542469 @default.
- W2912471813 cites W2127060205 @default.
- W2912471813 cites W2142110193 @default.
- W2912471813 cites W2150367899 @default.
- W2912471813 cites W2151995827 @default.
- W2912471813 cites W2172993862 @default.
- W2912471813 cites W2173604434 @default.
- W2912471813 cites W2398664613 @default.
- W2912471813 cites W2537578849 @default.
- W2912471813 cites W2550020881 @default.
- W2912471813 cites W2560348603 @default.
- W2912471813 cites W2562223138 @default.
- W2912471813 cites W2592711182 @default.
- W2912471813 cites W2594165111 @default.
- W2912471813 cites W2747355438 @default.
- W2912471813 cites W2755558750 @default.
- W2912471813 cites W2783935176 @default.
- W2912471813 cites W2792262108 @default.
- W2912471813 cites W4242305777 @default.
- W2912471813 cites W90330895 @default.
- W2912471813 doi "https://doi.org/10.1002/ptr.6293" @default.
- W2912471813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30729588" @default.
- W2912471813 hasPublicationYear "2019" @default.
- W2912471813 type Work @default.
- W2912471813 sameAs 2912471813 @default.
- W2912471813 citedByCount "8" @default.
- W2912471813 countsByYear W29124718132019 @default.
- W2912471813 countsByYear W29124718132020 @default.
- W2912471813 countsByYear W29124718132021 @default.
- W2912471813 countsByYear W29124718132022 @default.
- W2912471813 crossrefType "journal-article" @default.
- W2912471813 hasAuthorship W2912471813A5003667513 @default.
- W2912471813 hasAuthorship W2912471813A5015129046 @default.
- W2912471813 hasAuthorship W2912471813A5022644338 @default.
- W2912471813 hasAuthorship W2912471813A5026283201 @default.
- W2912471813 hasAuthorship W2912471813A5045272575 @default.
- W2912471813 hasAuthorship W2912471813A5050205808 @default.
- W2912471813 hasAuthorship W2912471813A5062073110 @default.
- W2912471813 hasAuthorship W2912471813A5069771785 @default.
- W2912471813 hasAuthorship W2912471813A5079036030 @default.
- W2912471813 hasAuthorship W2912471813A5091089849 @default.
- W2912471813 hasConcept C134018914 @default.
- W2912471813 hasConcept C165220095 @default.
- W2912471813 hasConcept C185592680 @default.
- W2912471813 hasConcept C2777130413 @default.
- W2912471813 hasConcept C2779306644 @default.
- W2912471813 hasConcept C2779525624 @default.
- W2912471813 hasConcept C2780705028 @default.
- W2912471813 hasConcept C48349386 @default.
- W2912471813 hasConcept C55493867 @default.