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- W2912472510 abstract "Abstract Therapies using human mesenchymal stem cells (MSCs) combined with three-dimensional (3D) printed scaffolds are a promising strategy for bone grafting. But the harvest of MSCs still remains invasive for patients. Human synovial fluid MSCs (hSF-MSCs), which can be obtained by a minimally invasive needle-aspiration procedure, have been used for cartilage repair. However, little is known of hSF-MSCs in bone regeneration. Polyetherketoneketone (PEKK) is an attractive bone scaffold due to its mechanical properties comparable to bone. In this study, 3D-printed PEKK scaffolds were fabricated using laser sintering technique. hSF-MSCs were characterized and cultured on PEKK to evaluate their cell attachment, proliferation, and osteogenic potential. Rabbit calvarial critical-sized bone defects were created to test the bone regenerative effect of PEKK with hSF-MSCs. In vitro results showed that hSF-MSCs attached, proliferated, and were osteogenic on PEKK. In vivo results indicated that PEKK seeded with hSF-MSCs regenerated twice the amount of newly formed bone when compared to PEKK seeded with osteogenically-induced hSF-MSCs or PEKK scaffolds alone. These results suggested that there was no need to induce hSF-MSCs into osteoblasts prior to their transplantations in vivo . In conclusion, the combined use of PEKK and hSF-MSCs was effective in regenerating critical-sized bone defects." @default.
- W2912472510 created "2019-02-21" @default.
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- W2912472510 date "2019-01-24" @default.
- W2912472510 modified "2023-10-06" @default.
- W2912472510 title "Combination of polyetherketoneketone scaffold and human mesenchymal stem cells from temporomandibular joint synovial fluid enhances bone regeneration" @default.
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- W2912472510 doi "https://doi.org/10.1038/s41598-018-36778-2" @default.
- W2912472510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6345789" @default.
- W2912472510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30679553" @default.
- W2912472510 hasPublicationYear "2019" @default.
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