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• W2912474350 abstract "Abstract Polypyrrole (pPy), a widely-used conductive material, can create an electrophysiological condition for the exogenous cardiomyocytes (CMs) via its conductivity, biocompatibility and available processing method. Our previously developed flexible scaffold from the mussel-derived chitosan shell possessed multiscale, interconnected-porous structure and proper stiffness, which was a promising tissue substitute for wound healing. Here, a 3D pristine hybrid scaffold was fabricated by incorporating polypyrrole into the mussel shell-derived membrane (shell-pPy). The pyrrole monomers were grafted onto to the shell membrane and then in situ polymerized to form conjugated pPy-chitosan shell using FeCl3. The developed pPy-chitosan shell was used to produce an engineered cardiac patch (ECP). The shell-pPy ECP maintained subtle spatial structure and was granted well cellular viability, aligned morphology, abundant striation and organized CX43, robust contraction and rapid calcium transients in vitro. When transplanted into the infarcted hearts, the developed shell-pPy ECP could also mimic the mechano-electronic function for cardiomyocytes maturation and integrity. Notably, obvious angiogenesis was triggered, and cardiac pumping performance was promoted in the infarcted area by the shell-pPy ECP. The study highlighted a functional pPy-modified cardiac patch with suitable conductivity, subtle 3D structure, and mechanical property can serve as an ideal ECP to mimic cardiac niche for myocardial repair." @default.
• W2912474350 created "2019-02-21" @default.
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• W2912474350 date "2019-06-01" @default.
• W2912474350 modified "2023-10-17" @default.
• W2912474350 title "In situ pPy-modification of chitosan porous membrane from mussel shell as a cardiac patch to repair myocardial infarction" @default.
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• W2912474350 doi "https://doi.org/10.1016/j.apmt.2019.01.003" @default.
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