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- W2912476634 abstract "Le diabète de type 2 (DT2) est une maladie héréditaire qui résulte de l’interaction gène/ environnement. L’influence de l’environnement sur l’expression des gènes, passerait par des modifications de l’épigénome sans altération de la séquence de l’ADN. Celles-ci ont pour conséquence un décompactage de la chromatine à certains endroits du génome qui est associé à une augmentation de l’expression des gènes par accessibilité accrue des régions régulatrices de ces gènes. Dans cet article, nous expliquons certains mécanismes épigénétiques, et nous rapportons les premiers travaux qui ont relié l’état inflammatoire du DT2 à des altérations épigénétiques. Type 2 diabetes (T2D) is an inherited disease that results from a gene/environment interaction. The influence of environment on the expression of genes would go through modifications of the epigenome without altering the sequence of DNA. These modifications result to chromatin decompacting at certain parts of the genome that is associated with a higher gene expression by increasing accessibility of the regulatory regions of these genes. In this article, we explain some epigenetic mechanisms, and we report the early work that linked the inflammatory state of T2D to epigenetic alterations." @default.
- W2912476634 created "2019-02-21" @default.
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- W2912476634 date "2019-02-01" @default.
- W2912476634 modified "2023-09-30" @default.
- W2912476634 title "Le déchiffrage de l’épigénome va-t-il révolutionner la compréhension et la prise en charge du diabète de type 2 ?" @default.
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- W2912476634 doi "https://doi.org/10.1016/s1957-2557(19)30024-0" @default.
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