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• W2912476719 abstract "Intestinal barrier dysfunction is a key etiologic factor of irritable bowel syndrome (IBS). Metformin improves intestinal barrier function, although the underlying mechanism has yet to be fully explained. This study evaluates the protective effect of metformin on colonic barrier integrity and explores the underlying cellular mechanisms.IBS-like rats were induced by maternal separation. Metformin was administered daily by gavage at 08:30, and rat pups were then separated from their mother. Visceral hyperalgesia and depression-like behaviors were evaluated by colorectal distension, sucrose preference tests, and forced swimming tests. Intestinal integrity was analyzed using sugar probes and transmission electron microscopy. Inflammatory factors and the levels of corticotropin-releasing factor were assessed by PCR and ELISA. The number of mast cells was evaluated by toluidine blue staining. Protein expression and localization were determined using Western blot and immunochemistry.Metformin pretreatment (a) reduced visceral hypersensitivity to colorectal distension, immobility time and enhanced sucrose consumption; (b) decreased urine lactulose/mannitol ratio and sucralose output; (c) inhibited the dilation of tight junction and prevented claudin-4 translocation; (d) inhibited mast cell activation and downregulated the expression of IL-6, IL-18, tryptase, PAR-2, and ERK activation; (e) inhibited claudin-4 phosphorylation at serine sites and interactions between clau-4 and ZO-1.Metformin may block mast cell activation to reduce PAR-2 expression and subsequently inhibit ERK activation and clau-4 phosphorylation at serine sites to normalize the interaction of clau-4 and ZO-1 and clau-4 distribution. Metformin may be clinically beneficial for patients with IBS or IBS-like symptoms." @default.
• W2912476719 created "2019-02-21" @default.
• W2912476719 creator A5009368703 @default.
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• W2912476719 date "2019-02-10" @default.
• W2912476719 modified "2023-10-04" @default.
• W2912476719 title "Metformin prevents colonic barrier dysfunction by inhibiting mast cell activation in maternal separation‐induced IBS‐like rats" @default.
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• W2912476719 cites W1843991022 @default.
• W2912476719 cites W1895653898 @default.
• W2912476719 cites W1897161389 @default.
• W2912476719 cites W1966776937 @default.
• W2912476719 cites W1966805395 @default.
• W2912476719 cites W2001998049 @default.
• W2912476719 cites W2013566024 @default.
• W2912476719 cites W2013598219 @default.
• W2912476719 cites W2015703748 @default.
• W2912476719 cites W2020525013 @default.
• W2912476719 cites W2023343492 @default.
• W2912476719 cites W2025726844 @default.
• W2912476719 cites W2040509610 @default.
• W2912476719 cites W2042232360 @default.
• W2912476719 cites W2042371226 @default.
• W2912476719 cites W2045798922 @default.
• W2912476719 cites W2046395686 @default.
• W2912476719 cites W2046497206 @default.
• W2912476719 cites W2049736579 @default.
• W2912476719 cites W2052749982 @default.
• W2912476719 cites W2054376706 @default.
• W2912476719 cites W2066198202 @default.
• W2912476719 cites W2072106617 @default.
• W2912476719 cites W2074997802 @default.
• W2912476719 cites W2076998894 @default.
• W2912476719 cites W2086798106 @default.
• W2912476719 cites W2089180209 @default.
• W2912476719 cites W2090270491 @default.
• W2912476719 cites W2097576923 @default.
• W2912476719 cites W2106113562 @default.
• W2912476719 cites W2111819970 @default.
• W2912476719 cites W2118752824 @default.
• W2912476719 cites W2123230988 @default.
• W2912476719 cites W2129920713 @default.
• W2912476719 cites W2131197173 @default.
• W2912476719 cites W2133808995 @default.
• W2912476719 cites W2135453228 @default.
• W2912476719 cites W2139334262 @default.
• W2912476719 cites W2141136779 @default.
• W2912476719 cites W2144750725 @default.
• W2912476719 cites W2146548337 @default.
• W2912476719 cites W2149032584 @default.
• W2912476719 cites W2152336072 @default.
• W2912476719 cites W2152839556 @default.
• W2912476719 cites W2155337537 @default.
• W2912476719 cites W2161238054 @default.
• W2912476719 cites W2167006636 @default.
• W2912476719 cites W2171931264 @default.
• W2912476719 cites W2194338180 @default.
• W2912476719 cites W2309469789 @default.
• W2912476719 cites W2337810595 @default.
• W2912476719 cites W2346180964 @default.
• W2912476719 cites W2410552124 @default.
• W2912476719 cites W2473725818 @default.
• W2912476719 cites W2474312581 @default.
• W2912476719 cites W2564435762 @default.
• W2912476719 cites W2565774918 @default.
• W2912476719 cites W2597445613 @default.
• W2912476719 cites W2608571065 @default.
• W2912476719 cites W2617940752 @default.
• W2912476719 cites W2735217644 @default.
• W2912476719 cites W2735693687 @default.
• W2912476719 cites W2740693801 @default.
• W2912476719 cites W2749836129 @default.
• W2912476719 cites W2751288039 @default.
• W2912476719 cites W2760242482 @default.
• W2912476719 cites W2764258509 @default.
• W2912476719 cites W2769332474 @default.
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• W2912476719 doi "https://doi.org/10.1111/nmo.13556" @default.
• W2912476719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30740845" @default.
• W2912476719 hasPublicationYear "2019" @default.
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