FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912476769> ?p ?o ?g. }

• W2912476769 endingPage "2873" @default.
• W2912476769 startingPage "2860" @default.
• W2912476769 abstract "Abstract Purpose: To identify deregulated and inhibitory miRNAs and generate novel mimics for replacement nanomedicine for head and neck squamous cell carcinomas (HNSCC). Experimental Design: We integrated miRNA and mRNA expression, copy number variation, and DNA methylation results from The Cancer Genome Atlas (TCGA), with a functional genome-wide screen. Results: We reveal that the miR-30 family is commonly repressed, and all 5 members sharing these seed sequence similarly inhibit HNSCC proliferation in vitro. We uncover a previously unrecognized inverse relationship with overexpression of a network of important predicted target mRNAs deregulated in HNSCC, that includes key molecules involved in proliferation (EGFR, MET, IGF1R, IRS1, E2F7), differentiation (WNT7B, FZD2), adhesion, and invasion (ITGA6, SERPINE1). Reexpression of the most differentially repressed family member, miR-30a-5p, suppressed this mRNA program, selected signaling proteins and pathways, and inhibited cell proliferation, migration, and invasion in vitro. Furthermore, a novel miR-30a-5p mimic formulated into a targeted nanomedicine significantly inhibited HNSCC xenograft tumor growth and target growth receptors EGFR and MET in vivo. Significantly decreased miR-30a/e family expression was related to DNA promoter hypermethylation and/or copy loss in TCGA data, and clinically with decreased disease-specific survival in a validation dataset. Strikingly, decreased miR-30e-5p distinguished oropharyngeal HNSCC with poor prognosis in TCGA (P = 0.002) and validation (P = 0.007) datasets, identifying a novel candidate biomarker and target for this HNSCC subset. Conclusions: We identify the miR-30 family as an important regulator of signal networks and tumor suppressor in a subset of HNSCC patients, which may benefit from miRNA replacement nanomedicine therapy." @default.
• W2912476769 created "2019-02-21" @default.
• W2912476769 creator A5018443439 @default.
• W2912476769 creator A5025724417 @default.
• W2912476769 creator A5025877720 @default.
• W2912476769 creator A5029970557 @default.
• W2912476769 creator A5030622261 @default.
• W2912476769 creator A5031516267 @default.
• W2912476769 creator A5033564940 @default.
• W2912476769 creator A5039264253 @default.
• W2912476769 creator A5044237462 @default.
• W2912476769 creator A5047405531 @default.
• W2912476769 creator A5048889250 @default.
• W2912476769 creator A5053434635 @default.
• W2912476769 creator A5053441593 @default.
• W2912476769 creator A5059327438 @default.
• W2912476769 creator A5060422349 @default.
• W2912476769 creator A5062939544 @default.
• W2912476769 creator A5063029120 @default.
• W2912476769 creator A5067770777 @default.
• W2912476769 creator A5067960602 @default.
• W2912476769 creator A5069913800 @default.
• W2912476769 creator A5072955574 @default.
• W2912476769 creator A5080866337 @default.
• W2912476769 creator A5081694359 @default.
• W2912476769 creator A5088560851 @default.
• W2912476769 creator A5088864413 @default.
• W2912476769 creator A5090412207 @default.
• W2912476769 date "2019-05-01" @default.
• W2912476769 modified "2023-10-14" @default.
• W2912476769 title "Integrated Genomic and Functional microRNA Analysis Identifies miR-30-5p as a Tumor Suppressor and Potential Therapeutic Nanomedicine in Head and Neck Cancer" @default.
• W2912476769 cites W1913893878 @default.
• W2912476769 cites W1967220865 @default.
• W2912476769 cites W1983266682 @default.
• W2912476769 cites W1985908128 @default.
• W2912476769 cites W1986241711 @default.
• W2912476769 cites W1993174948 @default.
• W2912476769 cites W1996460785 @default.
• W2912476769 cites W1998605742 @default.
• W2912476769 cites W1999574084 @default.
• W2912476769 cites W2000040240 @default.
• W2912476769 cites W2001019246 @default.
• W2912476769 cites W2001150039 @default.
• W2912476769 cites W2011528645 @default.
• W2912476769 cites W2016413200 @default.
• W2912476769 cites W2019459677 @default.
• W2912476769 cites W2024044726 @default.
• W2912476769 cites W2031432800 @default.
• W2912476769 cites W2033624346 @default.
• W2912476769 cites W2037207845 @default.
• W2912476769 cites W2045755466 @default.
• W2912476769 cites W2047895710 @default.
• W2912476769 cites W2058548073 @default.
• W2912476769 cites W2059806955 @default.
• W2912476769 cites W2063082743 @default.
• W2912476769 cites W2080738413 @default.
• W2912476769 cites W2082303527 @default.
• W2912476769 cites W2084218374 @default.
• W2912476769 cites W2085225921 @default.
• W2912476769 cites W2087772339 @default.
• W2912476769 cites W2089737806 @default.
• W2912476769 cites W2094211595 @default.
• W2912476769 cites W2100265462 @default.
• W2912476769 cites W2105260398 @default.
• W2912476769 cites W2111023369 @default.
• W2912476769 cites W2119483772 @default.
• W2912476769 cites W2121901052 @default.
• W2912476769 cites W2130785219 @default.
• W2912476769 cites W2133370964 @default.
• W2912476769 cites W2144832461 @default.
• W2912476769 cites W2150225606 @default.
• W2912476769 cites W2165759865 @default.
• W2912476769 cites W2168391904 @default.
• W2912476769 cites W2168561401 @default.
• W2912476769 cites W2169821574 @default.
• W2912476769 cites W2217465281 @default.
• W2912476769 cites W4255169631 @default.
• W2912476769 doi "https://doi.org/10.1158/1078-0432.ccr-18-0716" @default.
• W2912476769 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6497577" @default.
• W2912476769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30723145" @default.
• W2912476769 hasPublicationYear "2019" @default.
• W2912476769 type Work @default.
• W2912476769 sameAs 2912476769 @default.
• W2912476769 citedByCount "63" @default.
• W2912476769 countsByYear W29124767692019 @default.
• W2912476769 countsByYear W29124767692020 @default.
• W2912476769 countsByYear W29124767692021 @default.
• W2912476769 countsByYear W29124767692022 @default.
• W2912476769 countsByYear W29124767692023 @default.
• W2912476769 crossrefType "journal-article" @default.
• W2912476769 hasAuthorship W2912476769A5018443439 @default.
• W2912476769 hasAuthorship W2912476769A5025724417 @default.
• W2912476769 hasAuthorship W2912476769A5025877720 @default.
• W2912476769 hasAuthorship W2912476769A5029970557 @default.
• W2912476769 hasAuthorship W2912476769A5030622261 @default.
• W2912476769 hasAuthorship W2912476769A5031516267 @default.
• W2912476769 hasAuthorship W2912476769A5033564940 @default.
• W2912476769 hasAuthorship W2912476769A5039264253 @default.

• next