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- W2912478538 abstract "Mechanisms of proton transport regulation in mitochondria Elena E. Pohl Institute of Physiology, Pathophysiology and Biophysics, University of Veterinary Medicine Vienna Protein-mediated proton transport contributes to the proton-motive force in mitochondria and is therefore important for the variety of voltage-dependent processes, including the production of ATP and heat. Several membrane proteins such as uncoupling proteins (UCP), ATP/ADP carrier (ANT), and phosphate carrier are associated with H+ transport. It is tightly regulated; however, the underlying molecular mechanisms are highly debated1,2. I discuss existing models of UCP activation and inhibition, as well as proposed regulators. References 1 Macher, G. et al. Inhibition of mitochondrial UCP1 and UCP3 by purine nucleotides and phosphate. Biochim Biophys Acta 1860, 664-672, https://doi.org/10.1016/j.bbamem.2017.12.001 (2018). 2 Jezek, P., Holendova, B., Garlid, K. D. & Jaburek, M. Mitochondrial uncoupling proteins: subtle regulators of cellular redox signaling. Antioxid Redox Signal, https://doi.org/10.1089/ars.2017.7225 (2018)." @default.
- W2912478538 created "2019-02-21" @default.
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- W2912478538 date "2019-02-01" @default.
- W2912478538 modified "2023-09-26" @default.
- W2912478538 title "Regulation of the Proton Leak in Mitochondria" @default.
- W2912478538 doi "https://doi.org/10.1016/j.bpj.2018.11.1459" @default.
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