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- W2912479470 abstract "Introduction: Some studies suggest that early life bisphenol A (BPA) exposure may increase the risk of childhood obesity and this association may vary by child sex. There are few prospective studies with serial BPA exposure that can identify distinct windows of vulnerability. Methods: We investigated if prenatal or early childhood BPA exposure was associated with increased body mass index (BMI) at 2-5 years of age in 297 mother-child pairs from Cincinnati, OH. Urinary BPA concentrations were measured using mass spectrometry in samples collected from pregnant women during the 2nd and 3rd trimesters and their children at 1 and 2 years of age. BMI z-scores were calculated from weight and height measured annually from 2-5 years of age. We used multivariable linear mixed models to quantify the association between mean prenatal or mean early childhood BPA creatinine-standardized concentrations and BMI changes or trajectories after adjusting for socioeconomic, demographic, and perinatal, factors. Results: After confounder adjustment, a 10-fold increase in prenatal (β:-0.1, 95% confidence interval [CI]:-0.5, 0.3) or early childhood (β:-0.2, CI:-0.6, 0.1) BPA concentrations was not associated with increased BMI. Inverse associations between prenatal (effect measure modification p-value=0.23) or early childhood (effect measure modification p-value=0.07) BPA concentrations and BMI were suggestively stronger in girls than boys. Children in the highest early childhood BPA tercile (β:0.12; CI:0.07, 0.17) had more rapid (effect measure modification p-value=0.16) BMI gains from 2-5 years than children in the lowest tercile (β 0.07; CI:0.01, 0.12). Conclusions: Early life BPA exposures were not associated with increased BMI at 2-5 years of age, but higher early childhood BPA exposures were associated with more rapid increases in BMI. Future studies should consider examining confounding factors related to diet and compare methods of adjusting for early childhood urine dilution." @default.
- W2912479470 created "2019-02-21" @default.
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- W2912479470 date "2014-10-20" @default.
- W2912479470 modified "2023-09-26" @default.
- W2912479470 title "Early Life Bisphenol a Exposure and Child Body Mass Index: a Prospective Cohort Study" @default.
- W2912479470 doi "https://doi.org/10.1289/isee.2014.o-300" @default.
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