FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912483692> ?p ?o ?g. }

• W2912483692 abstract "Abstract There is strong evidence supporting the association between Alzheimer’s disease (AD) and protein-coding variants, R47H and R62H in TREM2 . The TREM2 protein is an immune receptor found in brain microglia. A structural alteration could therefore have a large effect on the protein. Crystallised structures were used as a base for both WT and mutated proteins. These subjected to 300ns of molecular dynamic simulation (MD). Results suggest structural alterations in both mutated forms of TREM2. A large change was noted in the R47H simulation in the complementarity-determining region two (CDR2) binding loop, a proposed binding sites for ligands such as APOE, a smaller change was observed in the R62H model. These differing levels of structural impact could explain the in vitro observed differences in TREM2-ligand binding. Author Summary A number of mutations have been found in the TREM2 protein in populations of people with Alzheimer’s and other dementias. Two of these mutations are similar in that the both cause the same coding change in the same domain of the protein. However, they both cause a very different result in terms of risk and in vitro observed changes. Why these two similar mutations are so different is largely unknown. Here we have used a in silico, simulation, approach to understanding the structural changes which occur in both of the mutations. Our results suggest that the mutation which carries a higher risk, but it less commonly observed, has a much larger impact on the protein structure than the mutation which is thought to be less damaging. This structural change is observed at a part of the protein which is thought to code for a binding loop and a change here could have a big impact on the proteins function. Further studies to investigate this binding loop could help not only a better understanding of TREM2’s role in the onset of dementia but also possibly provide a target for therapeutics." @default.
• W2912483692 created "2019-02-21" @default.
• W2912483692 creator A5001679374 @default.
• W2912483692 creator A5040508278 @default.
• W2912483692 creator A5060729138 @default.
• W2912483692 date "2019-01-31" @default.
• W2912483692 modified "2023-10-16" @default.
• W2912483692 title "Molecular Dynamics simulations of Alzheimer’s variants, R47H and R62H, in TREM2 provide evidence for structural alterations behind functional changes" @default.
• W2912483692 cites W1770378670 @default.
• W2912483692 cites W1974832498 @default.
• W2912483692 cites W2000647523 @default.
• W2912483692 cites W2031991074 @default.
• W2912483692 cites W2033068651 @default.
• W2912483692 cites W2036603197 @default.
• W2912483692 cites W2075175318 @default.
• W2912483692 cites W2085217889 @default.
• W2912483692 cites W2112480941 @default.
• W2912483692 cites W2115779804 @default.
• W2912483692 cites W2124490243 @default.
• W2912483692 cites W2128613449 @default.
• W2912483692 cites W2136513422 @default.
• W2912483692 cites W2160544821 @default.
• W2912483692 cites W2195303995 @default.
• W2912483692 cites W2482717739 @default.
• W2912483692 cites W2562065042 @default.
• W2912483692 cites W2573907086 @default.
• W2912483692 cites W2592518050 @default.
• W2912483692 cites W2601545624 @default.
• W2912483692 cites W2759351857 @default.
• W2912483692 cites W2793872352 @default.
• W2912483692 cites W2801885674 @default.
• W2912483692 cites W2803198382 @default.
• W2912483692 cites W2803254201 @default.
• W2912483692 cites W2916078022 @default.
• W2912483692 doi "https://doi.org/10.1101/536540" @default.
• W2912483692 hasPublicationYear "2019" @default.
• W2912483692 type Work @default.
• W2912483692 sameAs 2912483692 @default.
• W2912483692 citedByCount "2" @default.
• W2912483692 countsByYear W29124836922019 @default.
• W2912483692 countsByYear W29124836922020 @default.
• W2912483692 crossrefType "posted-content" @default.
• W2912483692 hasAuthorship W2912483692A5001679374 @default.
• W2912483692 hasAuthorship W2912483692A5040508278 @default.
• W2912483692 hasAuthorship W2912483692A5060729138 @default.
• W2912483692 hasBestOaLocation W29124836921 @default.
• W2912483692 hasConcept C104317684 @default.
• W2912483692 hasConcept C147597530 @default.
• W2912483692 hasConcept C170493617 @default.
• W2912483692 hasConcept C185592680 @default.
• W2912483692 hasConcept C2775905019 @default.
• W2912483692 hasConcept C2779685842 @default.
• W2912483692 hasConcept C2994430510 @default.
• W2912483692 hasConcept C47701112 @default.
• W2912483692 hasConcept C501734568 @default.
• W2912483692 hasConcept C54355233 @default.
• W2912483692 hasConcept C55493867 @default.
• W2912483692 hasConcept C59593255 @default.
• W2912483692 hasConcept C70721500 @default.
• W2912483692 hasConcept C86803240 @default.
• W2912483692 hasConceptScore W2912483692C104317684 @default.
• W2912483692 hasConceptScore W2912483692C147597530 @default.
• W2912483692 hasConceptScore W2912483692C170493617 @default.
• W2912483692 hasConceptScore W2912483692C185592680 @default.
• W2912483692 hasConceptScore W2912483692C2775905019 @default.
• W2912483692 hasConceptScore W2912483692C2779685842 @default.
• W2912483692 hasConceptScore W2912483692C2994430510 @default.
• W2912483692 hasConceptScore W2912483692C47701112 @default.
• W2912483692 hasConceptScore W2912483692C501734568 @default.
• W2912483692 hasConceptScore W2912483692C54355233 @default.
• W2912483692 hasConceptScore W2912483692C55493867 @default.
• W2912483692 hasConceptScore W2912483692C59593255 @default.
• W2912483692 hasConceptScore W2912483692C70721500 @default.
• W2912483692 hasConceptScore W2912483692C86803240 @default.
• W2912483692 hasLocation W29124836921 @default.
• W2912483692 hasOpenAccess W2912483692 @default.
• W2912483692 hasPrimaryLocation W29124836921 @default.
• W2912483692 hasRelatedWork W2035174476 @default.
• W2912483692 hasRelatedWork W2058328593 @default.
• W2912483692 hasRelatedWork W2079317986 @default.
• W2912483692 hasRelatedWork W2185132163 @default.
• W2912483692 hasRelatedWork W2520077781 @default.
• W2912483692 hasRelatedWork W2809286082 @default.
• W2912483692 hasRelatedWork W2890862392 @default.
• W2912483692 hasRelatedWork W2955742566 @default.
• W2912483692 hasRelatedWork W2988538745 @default.
• W2912483692 hasRelatedWork W2996550563 @default.
• W2912483692 hasRelatedWork W2999084109 @default.
• W2912483692 hasRelatedWork W3014065696 @default.
• W2912483692 hasRelatedWork W3034991810 @default.
• W2912483692 hasRelatedWork W3045673299 @default.
• W2912483692 hasRelatedWork W3046947066 @default.
• W2912483692 hasRelatedWork W3194417130 @default.
• W2912483692 hasRelatedWork W658915987 @default.
• W2912483692 hasRelatedWork W2181491059 @default.
• W2912483692 hasRelatedWork W2181593431 @default.
• W2912483692 hasRelatedWork W2466649545 @default.
• W2912483692 isParatext "false" @default.
• W2912483692 isRetracted "false" @default.
• W2912483692 magId "2912483692" @default.

• next