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- W2912485245 abstract "Calcium supplements are broadly prescribed to treat osteoporosis either as monotherapy or together with vitamin D to enhance calcium absorption. It is still unclear whether calcium supplementation significantly contributes to the reduction of bone fragility and fracture risk. Data suggest that supplementing post-menopausal women with high doses of calcium has a detrimental impact on cardiovascular morbidity and mortality. Chronic kidney disease (CKD) patients are prone to vascular calcification in part due to impaired phosphate excretion. Calcium-based phosphate binders further increase risk of vascular calcification progression. In both bone and vascular tissue, vitamin K-dependent processes play an important role in calcium homeostasis and it is tempting to speculate that vitamin K supplementation might protect from the potentially untoward effects of calcium supplementation. This review provides an update on current literature on calcium supplementation among post-menopausal women and CKD patients and discusses underlying molecular mechanisms of vascular calcification. We propose therapeutic strategies with vitamin K2 treatment to prevent or hold progression of vascular calcification as a consequence of excessive calcium intake." @default.
- W2912485245 created "2019-02-21" @default.
- W2912485245 creator A5015601819 @default.
- W2912485245 creator A5040355091 @default.
- W2912485245 creator A5070811893 @default.
- W2912485245 date "2019-02-05" @default.
- W2912485245 modified "2023-10-17" @default.
- W2912485245 title "The Bone—Vasculature Axis: Calcium Supplementation and the Role of Vitamin K" @default.
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