Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912485591> ?p ?o ?g. }
- W2912485591 abstract "Abstract Aberrant expression of neuropilin and tolloid-like 2 (NETO2) has been observed during the progression of some human carcinomas. However, the expression pattern and clinical relevance of NETO2 in gastric cancer (GC) remain to be elucidated. In this study, we found that NETO2 expression was higher in GC tissues compared with paired non-cancerous tissues. Moreover, the expression of NETO2 was positively correlated with clinical stage, invasion depth, lymph node metastasis, and tumor size, but inversely correlated with overall and disease-free survival rates. Cox regression analysis identified NETO2 as an independent prognostic indicator for GC patients. Overexpression of NETO2 facilitated migration and invasion of GC cells in vitro and metastasis in vivo in association with induction of epithelial-mesenchymal transition. Conversely, knockdown of NETO2 had the opposite effects. Mechanistically, silencing NETO2 reduced the phosphorylation of PI3K, AKT, and NF-κB p65 as well as the expression of Snail, whereas NETO2 overexpression achieved the opposite results. Furthermore, we identified TNFRSF12A as a mediator for NETO2 to activate PI3K/AKT/NF-κB/Snail axis. Collectively, our results demonstrate that NETO2 promotes invasion and metastasis of GC cells and represents a novel prognostic indicator as well as a potential therapeutic target in GC." @default.
- W2912485591 created "2019-02-21" @default.
- W2912485591 creator A5003642180 @default.
- W2912485591 creator A5025978909 @default.
- W2912485591 creator A5038328765 @default.
- W2912485591 creator A5051310867 @default.
- W2912485591 creator A5052226142 @default.
- W2912485591 creator A5053403537 @default.
- W2912485591 creator A5056174700 @default.
- W2912485591 creator A5061261246 @default.
- W2912485591 creator A5068591936 @default.
- W2912485591 creator A5070578608 @default.
- W2912485591 creator A5080562594 @default.
- W2912485591 creator A5085399047 @default.
- W2912485591 creator A5087949256 @default.
- W2912485591 date "2019-02-15" @default.
- W2912485591 modified "2023-10-17" @default.
- W2912485591 title "NETO2 promotes invasion and metastasis of gastric cancer cells via activation of PI3K/Akt/NF-κB/Snail axis and predicts outcome of the patients" @default.
- W2912485591 cites W1552952000 @default.
- W2912485591 cites W1849856438 @default.
- W2912485591 cites W1906566368 @default.
- W2912485591 cites W1963786372 @default.
- W2912485591 cites W1981223981 @default.
- W2912485591 cites W1983074899 @default.
- W2912485591 cites W1989012283 @default.
- W2912485591 cites W2002729585 @default.
- W2912485591 cites W2006444511 @default.
- W2912485591 cites W2007086998 @default.
- W2912485591 cites W2012615147 @default.
- W2912485591 cites W2019217555 @default.
- W2912485591 cites W2021847568 @default.
- W2912485591 cites W2023029839 @default.
- W2912485591 cites W2024238607 @default.
- W2912485591 cites W2026872153 @default.
- W2912485591 cites W2033962173 @default.
- W2912485591 cites W2036105610 @default.
- W2912485591 cites W2036802163 @default.
- W2912485591 cites W2061843980 @default.
- W2912485591 cites W2062726330 @default.
- W2912485591 cites W2063011414 @default.
- W2912485591 cites W2072451946 @default.
- W2912485591 cites W2074145410 @default.
- W2912485591 cites W2077793876 @default.
- W2912485591 cites W2080870285 @default.
- W2912485591 cites W2089286771 @default.
- W2912485591 cites W2095330800 @default.
- W2912485591 cites W2107312134 @default.
- W2912485591 cites W2109127924 @default.
- W2912485591 cites W2114570899 @default.
- W2912485591 cites W2123700568 @default.
- W2912485591 cites W2127712585 @default.
- W2912485591 cites W2131419607 @default.
- W2912485591 cites W2133650808 @default.
- W2912485591 cites W2137203885 @default.
- W2912485591 cites W2157379134 @default.
- W2912485591 cites W2160697532 @default.
- W2912485591 cites W2169168196 @default.
- W2912485591 cites W2170552969 @default.
- W2912485591 cites W2235523093 @default.
- W2912485591 cites W2237809442 @default.
- W2912485591 cites W2303497879 @default.
- W2912485591 cites W2463600666 @default.
- W2912485591 cites W2522393195 @default.
- W2912485591 cites W2531066740 @default.
- W2912485591 cites W2560443178 @default.
- W2912485591 cites W2570618306 @default.
- W2912485591 cites W2587894118 @default.
- W2912485591 cites W2590035643 @default.
- W2912485591 cites W2607129810 @default.
- W2912485591 cites W2737785069 @default.
- W2912485591 cites W2746697572 @default.
- W2912485591 cites W2780367089 @default.
- W2912485591 cites W2781008432 @default.
- W2912485591 cites W2783337717 @default.
- W2912485591 cites W2789466173 @default.
- W2912485591 cites W2798231099 @default.
- W2912485591 cites W2803030655 @default.
- W2912485591 cites W2884231755 @default.
- W2912485591 cites W2885532026 @default.
- W2912485591 cites W2893219036 @default.
- W2912485591 cites W2990315986 @default.
- W2912485591 cites W4211130279 @default.
- W2912485591 doi "https://doi.org/10.1038/s41419-019-1388-5" @default.
- W2912485591 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6377647" @default.
- W2912485591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30770791" @default.
- W2912485591 hasPublicationYear "2019" @default.
- W2912485591 type Work @default.
- W2912485591 sameAs 2912485591 @default.
- W2912485591 citedByCount "46" @default.
- W2912485591 countsByYear W29124855912019 @default.
- W2912485591 countsByYear W29124855912020 @default.
- W2912485591 countsByYear W29124855912021 @default.
- W2912485591 countsByYear W29124855912022 @default.
- W2912485591 countsByYear W29124855912023 @default.
- W2912485591 crossrefType "journal-article" @default.
- W2912485591 hasAuthorship W2912485591A5003642180 @default.
- W2912485591 hasAuthorship W2912485591A5025978909 @default.
- W2912485591 hasAuthorship W2912485591A5038328765 @default.
- W2912485591 hasAuthorship W2912485591A5051310867 @default.
- W2912485591 hasAuthorship W2912485591A5052226142 @default.