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- W2912486407 abstract "While the link between GBA and Parkinson's disease (PD) was initially unexpected, it is now well established that GBA mutations are the most frequent genetic risk for PD. GBA has also been linked to sporadic PD, dementia with Lewy bodies, and ageing. Thus, GBA represents a promising target to counteract brain disease and the age-related decline of lysosomal function. The exact mechanisms involved in the risk of developing PD in GBA mutation carriers are still unclear and research in this field has faced the major challenge of a lack of proper modeling systems. Induced pluripotent stem cells (iPSCs) as well as advances in disease modeling and genome editing have facilitated studies of human brain disease. With regard to GBA-PD, iPSCs offer several advantages including the possibility of investigating sphingolipid (SPL) biology in relevant cells, the role of dopamine metabolism as well as non-cell autonomous mechanisms that are likely involved in the disease process. This review will summarize findings that emerged from iPSC-based studies in the context of GBA-PD pathology and therapy. We also highlight current advantages and challenges of stem cell models for neurological disease modeling and drug discovery." @default.
- W2912486407 created "2019-02-21" @default.
- W2912486407 creator A5012747745 @default.
- W2912486407 creator A5056933907 @default.
- W2912486407 creator A5091287609 @default.
- W2912486407 date "2019-07-01" @default.
- W2912486407 modified "2023-10-17" @default.
- W2912486407 title "Insights into GBA Parkinson's disease pathology and therapy with induced pluripotent stem cell model systems" @default.
- W2912486407 cites W114818266 @default.
- W2912486407 cites W1420421568 @default.
- W2912486407 cites W1496067884 @default.
- W2912486407 cites W1517181973 @default.
- W2912486407 cites W1520064365 @default.
- W2912486407 cites W1561899360 @default.
- W2912486407 cites W1799409770 @default.
- W2912486407 cites W1841354354 @default.
- W2912486407 cites W1885594328 @default.
- W2912486407 cites W1886318170 @default.
- W2912486407 cites W1914859108 @default.
- W2912486407 cites W1964353444 @default.
- W2912486407 cites W1972277010 @default.
- W2912486407 cites W1973738022 @default.
- W2912486407 cites W1975932268 @default.
- W2912486407 cites W1977680862 @default.
- W2912486407 cites W1978129709 @default.
- W2912486407 cites W1981336920 @default.
- W2912486407 cites W1982224533 @default.
- W2912486407 cites W1985010554 @default.
- W2912486407 cites W1987155530 @default.
- W2912486407 cites W1990974805 @default.
- W2912486407 cites W1991844854 @default.
- W2912486407 cites W1991968375 @default.
- W2912486407 cites W1995959676 @default.
- W2912486407 cites W1996637092 @default.
- W2912486407 cites W1997604339 @default.
- W2912486407 cites W1999722943 @default.
- W2912486407 cites W2000365602 @default.
- W2912486407 cites W2003126320 @default.
- W2912486407 cites W2003171404 @default.
- W2912486407 cites W2004413662 @default.
- W2912486407 cites W2005853038 @default.
- W2912486407 cites W2005934624 @default.
- W2912486407 cites W2009711029 @default.
- W2912486407 cites W2010478595 @default.
- W2912486407 cites W2012438903 @default.
- W2912486407 cites W2018286352 @default.
- W2912486407 cites W2019895460 @default.
- W2912486407 cites W2026717532 @default.
- W2912486407 cites W2029028848 @default.
- W2912486407 cites W2031365272 @default.
- W2912486407 cites W2033799616 @default.
- W2912486407 cites W2035258856 @default.
- W2912486407 cites W2043822937 @default.
- W2912486407 cites W2046148946 @default.
- W2912486407 cites W2052612294 @default.
- W2912486407 cites W2053490488 @default.
- W2912486407 cites W2054646490 @default.
- W2912486407 cites W2055238728 @default.
- W2912486407 cites W2055487675 @default.
- W2912486407 cites W2057979657 @default.
- W2912486407 cites W2063540835 @default.
- W2912486407 cites W2064815984 @default.
- W2912486407 cites W2066498624 @default.
- W2912486407 cites W2066544389 @default.
- W2912486407 cites W2068015921 @default.
- W2912486407 cites W2068288454 @default.
- W2912486407 cites W2069363991 @default.
- W2912486407 cites W2071309923 @default.
- W2912486407 cites W2071494035 @default.
- W2912486407 cites W2076585244 @default.
- W2912486407 cites W2079133058 @default.
- W2912486407 cites W2079378641 @default.
- W2912486407 cites W2081014220 @default.
- W2912486407 cites W2081027701 @default.
- W2912486407 cites W2081102375 @default.
- W2912486407 cites W2082131511 @default.
- W2912486407 cites W2082307109 @default.
- W2912486407 cites W2087968969 @default.
- W2912486407 cites W2092011356 @default.
- W2912486407 cites W2092108054 @default.
- W2912486407 cites W2095850233 @default.
- W2912486407 cites W2099548919 @default.
- W2912486407 cites W2100600161 @default.
- W2912486407 cites W2102424187 @default.
- W2912486407 cites W2102600433 @default.
- W2912486407 cites W2103861487 @default.
- W2912486407 cites W2110335166 @default.
- W2912486407 cites W2117388188 @default.
- W2912486407 cites W2119508244 @default.
- W2912486407 cites W2120204888 @default.
- W2912486407 cites W2123746730 @default.
- W2912486407 cites W2126231259 @default.
- W2912486407 cites W2127513771 @default.
- W2912486407 cites W2128846833 @default.
- W2912486407 cites W2133958457 @default.
- W2912486407 cites W2135178483 @default.
- W2912486407 cites W2136230100 @default.
- W2912486407 cites W2137300912 @default.