Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912486502> ?p ?o ?g. }
- W2912486502 endingPage "1151" @default.
- W2912486502 startingPage "1129" @default.
- W2912486502 abstract "Epithelial-mesenchymal transition (EMT) contributes significantly to interstitial matrix deposition in diabetic kidney disease (DKD). However, detection of EMT in kidney tissue is impracticable, and anti-EMT therapies have long been hindered. We reported that phosphatase and tensin homolog (PTEN) promoted transforming growth factor beta 1 (TGF-β), sonic hedgehog (SHH), connective tissue growth factor (CTGF), interleukin 6 (IL-6), and hyperglycemia-induced EMT when PTEN was modified by a MEX3C-catalyzed K27-linked polyubiquitination at lysine 80 (referred to as PTENK27-polyUb). Genetic inhibition of PTENK27-polyUb alleviated Col4a3 knockout-, folic acid-, and streptozotocin-induced (STZ-induced) kidney injury. Serum and urine PTENK27-polyUb concentrations were negatively correlated with glomerular filtration rate (GFR) for diabetic patients. Mechanistically, PTENK27-polyUb facilitated dephosphorylation and protein stabilization of TWIST, SNAI1, and YAP in renal epithelial cells, leading to enhanced EMT. We identified that a small molecule, triptolide, inhibited MEX3C-catalyzed PTENK27-polyUb and EMT of renal epithelial cells. Treatment with triptolide reduced TWIST, SNAI1, and YAP concurrently and improved kidney health in Col4a3 knockout-, folic acid-injured disease models and STZ-induced, BTBR ob/ob diabetic nephropathy models. Hence, we demonstrated the important role of PTENK27-polyUb in DKD and a promising therapeutic strategy that inhibited the progression of DKD." @default.
- W2912486502 created "2019-02-21" @default.
- W2912486502 creator A5002078440 @default.
- W2912486502 creator A5012658757 @default.
- W2912486502 creator A5017947596 @default.
- W2912486502 creator A5018014617 @default.
- W2912486502 creator A5032652105 @default.
- W2912486502 creator A5036009269 @default.
- W2912486502 creator A5038549808 @default.
- W2912486502 creator A5040765980 @default.
- W2912486502 creator A5048715916 @default.
- W2912486502 creator A5052747073 @default.
- W2912486502 creator A5056177303 @default.
- W2912486502 creator A5063068082 @default.
- W2912486502 creator A5066521867 @default.
- W2912486502 creator A5069800720 @default.
- W2912486502 creator A5073804583 @default.
- W2912486502 creator A5076834432 @default.
- W2912486502 creator A5088959356 @default.
- W2912486502 date "2019-02-11" @default.
- W2912486502 modified "2023-10-13" @default.
- W2912486502 title "PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease" @default.
- W2912486502 cites W1204326888 @default.
- W2912486502 cites W1215049722 @default.
- W2912486502 cites W1489145507 @default.
- W2912486502 cites W1939083266 @default.
- W2912486502 cites W1965151940 @default.
- W2912486502 cites W1973921769 @default.
- W2912486502 cites W1976363248 @default.
- W2912486502 cites W1980982925 @default.
- W2912486502 cites W1988524540 @default.
- W2912486502 cites W1991167758 @default.
- W2912486502 cites W1995003323 @default.
- W2912486502 cites W1996141009 @default.
- W2912486502 cites W1998680204 @default.
- W2912486502 cites W2005032654 @default.
- W2912486502 cites W2011162627 @default.
- W2912486502 cites W2017739035 @default.
- W2912486502 cites W2029746669 @default.
- W2912486502 cites W2032942532 @default.
- W2912486502 cites W2033753222 @default.
- W2912486502 cites W2039648313 @default.
- W2912486502 cites W2049030581 @default.
- W2912486502 cites W2052092179 @default.
- W2912486502 cites W2055092042 @default.
- W2912486502 cites W2058272345 @default.
- W2912486502 cites W2060401077 @default.
- W2912486502 cites W2066717161 @default.
- W2912486502 cites W2075837574 @default.
- W2912486502 cites W2077854783 @default.
- W2912486502 cites W2081338931 @default.
- W2912486502 cites W2083325490 @default.
- W2912486502 cites W2100048287 @default.
- W2912486502 cites W2101209173 @default.
- W2912486502 cites W2102570939 @default.
- W2912486502 cites W2105701104 @default.
- W2912486502 cites W2108192985 @default.
- W2912486502 cites W2128569676 @default.
- W2912486502 cites W2134074039 @default.
- W2912486502 cites W2140754284 @default.
- W2912486502 cites W2143004704 @default.
- W2912486502 cites W2157373537 @default.
- W2912486502 cites W2160415688 @default.
- W2912486502 cites W2173661640 @default.
- W2912486502 cites W2189664213 @default.
- W2912486502 cites W2261992653 @default.
- W2912486502 cites W2286731838 @default.
- W2912486502 cites W2306843701 @default.
- W2912486502 cites W2318343874 @default.
- W2912486502 cites W2339921413 @default.
- W2912486502 cites W2342679639 @default.
- W2912486502 cites W2347076418 @default.
- W2912486502 cites W2582845364 @default.
- W2912486502 cites W2591074529 @default.
- W2912486502 cites W2749881696 @default.
- W2912486502 cites W2755922861 @default.
- W2912486502 cites W2795973792 @default.
- W2912486502 cites W4255618688 @default.
- W2912486502 cites W6760901 @default.
- W2912486502 doi "https://doi.org/10.1172/jci121987" @default.
- W2912486502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6391108" @default.
- W2912486502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30741721" @default.
- W2912486502 hasPublicationYear "2019" @default.
- W2912486502 type Work @default.
- W2912486502 sameAs 2912486502 @default.
- W2912486502 citedByCount "60" @default.
- W2912486502 countsByYear W29124865022019 @default.
- W2912486502 countsByYear W29124865022020 @default.
- W2912486502 countsByYear W29124865022021 @default.
- W2912486502 countsByYear W29124865022022 @default.
- W2912486502 countsByYear W29124865022023 @default.
- W2912486502 crossrefType "journal-article" @default.
- W2912486502 hasAuthorship W2912486502A5002078440 @default.
- W2912486502 hasAuthorship W2912486502A5012658757 @default.
- W2912486502 hasAuthorship W2912486502A5017947596 @default.
- W2912486502 hasAuthorship W2912486502A5018014617 @default.
- W2912486502 hasAuthorship W2912486502A5032652105 @default.
- W2912486502 hasAuthorship W2912486502A5036009269 @default.