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• W2912487815 startingPage "100332" @default.
• W2912487815 abstract "The effects of physical exercise in patients with lacunar stroke, seem promising in secondary prevention and only few studies have investigated the effect of high-intensity interval training in patients with lacunar stroke. This study will be investigating whether high-intensity interval training improves cardiovascular fitness as well as cognitive- and endothelial function and potentially attenuating the risk of recurrent stroke.A randomized controlled trial evaluating 12 weeks of home-based, high-intensity interval training compared with usual care. The intervention group will be exercising 15 min a day, 5 days a week, for 12 weeks. Outcomes will be evaluated at baseline, three, six and twelve months post-stroke with 'The Graded Cycling Test with Talk Test' as the primary outcome registered as power output in Watts. Additionally, an annually register-based follow-up will be performed for 5 years from date of inclusion with a composite endpoint of cardiovascular disease or death. Secondary outcomes will be: physical activity, endothelial response, mental well-being, cognition, mood, fatigue, stress, and MRI scan.This study is going to show if early initiated home-based high-intensity interval training is feasible and effective in patients with lacunar stroke. A self-chosen aerobic exercise modality allows a realistic implementation of practice, together with greater chance of long-term adherence. A limitation of the study is that recruitment bias cannot be ruled out, as there may be a preferential enrolment of patients who are self-motivated to engage in exercise." @default.
• W2912487815 created "2019-02-21" @default.
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• W2912487815 date "2019-06-01" @default.
• W2912487815 modified "2023-09-27" @default.
• W2912487815 title "Home-based aerobic exercise in patients with lacunar stroke: Design of the HITPALS randomized controlled trial" @default.
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• W2912487815 doi "https://doi.org/10.1016/j.conctc.2019.100332" @default.
• W2912487815 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6378897" @default.
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