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- W2912488239 abstract "Melanocytic tumors in Xiphophorus melanoma receptor kinase (xmrk)-transgenic Carbio and HB11A strains of medaka were examined histopathologically at 7 months post-hatching. Medaka of both strains developed melanocytic tumors with a penetrance of 100%. In both strains, neoplastic cells containing intracytoplasmic melanin pigment granules showed significant invasive growth patterns. In addition, epithelioid neoplastic cells were arranged in solid nests, and spindle neoplastic cells were arranged in interlacing streams and bundles. Nuclear atypia, anisokaryosis, cellular pleomorphism, and the appearance of anaplastic giant cells containing multiple nuclei or a single nucleus were observed in neoplastic lesions in both medaka strains. However, neither strain exhibited mitotic figures or invasion of blood vessels by neoplastic cells. Based on these histopathologic findings, the tumors were diagnosed as malignant melanoma. This is the first report of detailed histomorphologic characteristics of malignant melanoma in xmrk-transgenic medaka." @default.
- W2912488239 created "2019-02-21" @default.
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- W2912488239 date "2019-01-01" @default.
- W2912488239 modified "2023-10-14" @default.
- W2912488239 title "Histopathologic features of melanocytic tumors in <i>Xiphophorus</i> melanoma receptor kinase (<i>xmrk</i>)-transgenic medaka (<i>Oryzias latipes</i>)" @default.
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- W2912488239 doi "https://doi.org/10.1293/tox.2018-0058" @default.
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