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• W2912490007 endingPage "128" @default.
• W2912490007 startingPage "119" @default.
• W2912490007 abstract "It is well documented that synapses play a significant role in the transmission of information between neurons. However, in the absence of synaptic transmission, neural activity has been observed to continue to propagate. Previous studies have shown that propagation of epileptiform activity takes place in the absence of synaptic transmission and gap junctions and is outside the range of ionic diffusion and axonal conduction. Computer simulations indicate that electric field coupling could be responsible for the propagation of neural activity under pathological conditions such as epilepsy. Electric fields can modulate neuronal membrane voltage, but there is no experimental evidence suggesting that electric field coupling can mediate self-regenerating propagation of neural activity. Here we examine the role of electric field coupling by eliminating all forms of neural communications except electric field coupling with a cut through the neural tissue. We show that 4-AP induced activity generates an electric field capable of recruiting neurons on the distal side of the cut. Experiments also show that applied electric fields with amplitudes similar to endogenous values can induce propagating waves. Finally, we show that canceling the electrical field at a given point can block spontaneous propagation. The results from these in vitro electrophysiology experiments suggest that electric field coupling is a critical mechanism for non-synaptic neural propagation and therefore could contribute to the propagation of epileptic activity in the brain." @default.
• W2912490007 created "2019-02-21" @default.
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• W2912490007 date "2019-07-01" @default.
• W2912490007 modified "2023-10-17" @default.
• W2912490007 title "Self-propagating, non-synaptic epileptiform activity recruits neurons by endogenous electric fields" @default.
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• W2912490007 doi "https://doi.org/10.1016/j.expneurol.2019.02.005" @default.
• W2912490007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30776338" @default.
• W2912490007 hasPublicationYear "2019" @default.
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