FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912490442> ?p ?o ?g. }

• W2912490442 endingPage "1245" @default.
• W2912490442 startingPage "1232" @default.
• W2912490442 abstract "Abstract Lung cancer has the highest mortality rate due to late diagnosis and high incidence of metastasis. Cancer stem cells (CSCs) are a subgroup of cancer cells with self‐renewal capability similar to that of normal stem cells (NSCs). While CSCs may play an important role in cancer progression, mechanisms underlying CSC self‐renewal and the relationship between self‐renewal of the NSCs and CSCs remain elusive. The orphan nuclear receptor Nr5a2 is a transcriptional factor, and a regulator of stemness of embryonic stem cells and induced pluripotent stem cells. However, whether Nr5a2 regulates the self‐renewal of lung CSCs is unknown. Here, we showed the diagnostic and prognostic values of elevated Nr5a2 expression in human lung cancer. We generated the mouse LLC‐SD lung carcinoma CSC cellular model in which Nr5a2 expression was enhanced. Using the LLC‐SD model, through transient and stable siRNA interference of Nr5a2 expression, we provided convincing evidence for a regulatory role of Nr5a2 in the maintenance of lung CSC self‐renewal and stem cell properties in vitro. Further, using the syngeneic and orthotopic lung transplantation model, we elucidated augmented cancer biological properties associated with Nr5a2 promotion of LLC‐SD self‐renewal. More importantly, we revealed that Nr5a2 ’s regulatory role in promoting LLC‐SD self‐renewal is mediated by transcriptional activation of its direct target Nanog . Taken together, in this study, we have provided convincing evidence in vitro and in vivo demonstrating that Nr5a2 can induce lung CSC properties and promote tumorigenesis and progression through transcriptional up‐regulation of Nanog ." @default.
• W2912490442 created "2019-02-21" @default.
• W2912490442 creator A5025233131 @default.
• W2912490442 creator A5030902395 @default.
• W2912490442 creator A5038175120 @default.
• W2912490442 creator A5039962884 @default.
• W2912490442 creator A5046453107 @default.
• W2912490442 creator A5050613147 @default.
• W2912490442 creator A5050934360 @default.
• W2912490442 creator A5081935724 @default.
• W2912490442 creator A5087725251 @default.
• W2912490442 date "2019-02-10" @default.
• W2912490442 modified "2023-10-14" @default.
• W2912490442 title "<i>Nr5a2</i>promotes cancer stem cell properties and tumorigenesis in nonsmall cell lung cancer by regulating<i>Nanog</i>" @default.
• W2912490442 cites W1862724536 @default.
• W2912490442 cites W1963590109 @default.
• W2912490442 cites W1963981832 @default.
• W2912490442 cites W1978335582 @default.
• W2912490442 cites W1981348429 @default.
• W2912490442 cites W1991354119 @default.
• W2912490442 cites W1992514491 @default.
• W2912490442 cites W1992676863 @default.
• W2912490442 cites W1994599132 @default.
• W2912490442 cites W2000502676 @default.
• W2912490442 cites W2001544973 @default.
• W2912490442 cites W2009639026 @default.
• W2912490442 cites W2009886857 @default.
• W2912490442 cites W2014643937 @default.
• W2912490442 cites W2017287612 @default.
• W2912490442 cites W2023427658 @default.
• W2912490442 cites W2045519188 @default.
• W2912490442 cites W2048385227 @default.
• W2912490442 cites W2053113214 @default.
• W2912490442 cites W2053946898 @default.
• W2912490442 cites W2064589709 @default.
• W2912490442 cites W2068416436 @default.
• W2912490442 cites W2068458442 @default.
• W2912490442 cites W2080457126 @default.
• W2912490442 cites W2090982381 @default.
• W2912490442 cites W2091514601 @default.
• W2912490442 cites W2096942972 @default.
• W2912490442 cites W2109637992 @default.
• W2912490442 cites W2131170195 @default.
• W2912490442 cites W2159060826 @default.
• W2912490442 cites W2167786463 @default.
• W2912490442 cites W2184779060 @default.
• W2912490442 cites W2206592217 @default.
• W2912490442 cites W2280957887 @default.
• W2912490442 cites W2297970061 @default.
• W2912490442 cites W2313599265 @default.
• W2912490442 cites W2461342954 @default.
• W2912490442 cites W2504954641 @default.
• W2912490442 cites W2564726295 @default.
• W2912490442 cites W2624820921 @default.
• W2912490442 doi "https://doi.org/10.1002/cam4.1992" @default.
• W2912490442 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6434341" @default.
• W2912490442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30740909" @default.
• W2912490442 hasPublicationYear "2019" @default.
• W2912490442 type Work @default.
• W2912490442 sameAs 2912490442 @default.
• W2912490442 citedByCount "19" @default.
• W2912490442 countsByYear W29124904422019 @default.
• W2912490442 countsByYear W29124904422020 @default.
• W2912490442 countsByYear W29124904422021 @default.
• W2912490442 countsByYear W29124904422022 @default.
• W2912490442 countsByYear W29124904422023 @default.
• W2912490442 crossrefType "journal-article" @default.
• W2912490442 hasAuthorship W2912490442A5025233131 @default.
• W2912490442 hasAuthorship W2912490442A5030902395 @default.
• W2912490442 hasAuthorship W2912490442A5038175120 @default.
• W2912490442 hasAuthorship W2912490442A5039962884 @default.
• W2912490442 hasAuthorship W2912490442A5046453107 @default.
• W2912490442 hasAuthorship W2912490442A5050613147 @default.
• W2912490442 hasAuthorship W2912490442A5050934360 @default.
• W2912490442 hasAuthorship W2912490442A5081935724 @default.
• W2912490442 hasAuthorship W2912490442A5087725251 @default.
• W2912490442 hasBestOaLocation W29124904421 @default.
• W2912490442 hasConcept C104317684 @default.
• W2912490442 hasConcept C107459253 @default.
• W2912490442 hasConcept C121608353 @default.
• W2912490442 hasConcept C1292079 @default.
• W2912490442 hasConcept C142724271 @default.
• W2912490442 hasConcept C145103041 @default.
• W2912490442 hasConcept C207701140 @default.
• W2912490442 hasConcept C2776256026 @default.
• W2912490442 hasConcept C2779013556 @default.
• W2912490442 hasConcept C28328180 @default.
• W2912490442 hasConcept C502942594 @default.
• W2912490442 hasConcept C54355233 @default.
• W2912490442 hasConcept C55427017 @default.
• W2912490442 hasConcept C555283112 @default.
• W2912490442 hasConcept C71924100 @default.
• W2912490442 hasConcept C86339819 @default.
• W2912490442 hasConcept C86803240 @default.
• W2912490442 hasConcept C95444343 @default.
• W2912490442 hasConceptScore W2912490442C104317684 @default.
• W2912490442 hasConceptScore W2912490442C107459253 @default.
• W2912490442 hasConceptScore W2912490442C121608353 @default.

• next