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- W2912492816 abstract "Arachidonic acid is a 20-carbon cis-polyunsaturated fatty acid that is one of the most abundant fatty acids in the brain. Arachidonic acid is released following activation of postsynaptic glutamate receptors and can modulate the activity of glutamate transporters homologues in different ways. Application of arachidonic acid to salamander retina Müller cells causes prolonged inhibition of glutamate transport and the most abundant glutamate transporter subtype in salamander Müller cells is a homolog of EAAT1. Application of arachidonic acid to oocytes expressing EAAT4 in the presence of glutamate or aspartate induces a novel H+ current through the transporter. While arachidonic acid has a variety of functional effects on mammalian homologues, there are currently no published studies investigating the effects of lipid composition on GltPh, which has been crystalized in different states and serves as a great model for function study. In addition, in the crystal structures of GltPh there are a series of crevices that have been speculated to have the capacity to bind lipid modulators of transporters. Here we will study arachidonic homologues effect on GltPh and investigate the lipid binding sites in glutamate transporter." @default.
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- W2912492816 date "2019-02-01" @default.
- W2912492816 modified "2023-10-16" @default.
- W2912492816 title "Modulation of Glutamate Transporter Gltph by Arachidonic Acid Homologues" @default.
- W2912492816 doi "https://doi.org/10.1016/j.bpj.2018.11.1889" @default.
- W2912492816 hasPublicationYear "2019" @default.
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