Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912493033> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2912493033 endingPage "289" @default.
- W2912493033 startingPage "288" @default.
- W2912493033 abstract "Drugs that provide effective analgesia in cats are limited. The aim of the present study was to investigate the pharmacokinetics of the novel atypical drug tapentadol (TAP) after intravenous (IV), intramuscular (IM) and subcutaneous (SC) injection in six healthy cats using a 3 × 3 Latin square crossover study design. The dose rate used was 5 mg/kg and the concentrations of TAP in plasma were evaluated using high-performance liquid chromatography.Some adverse effects including salivation, agitation and panting, were noted, especially following IV administration. In all three administration groups, TAP concentrations were detectable in plasma for up to 8 h. Bioavailability for each route was almost complete, accounting for 94% and 90% after IM and SC administrations, respectively. Drug absorption was faster after IM than SC administration (0.25 h vs. 0.63 h). The half-life of the terminal portion of the plasma concentration curve was not significantly different between the three routes of administrations (2–3 h). TAP appears to have some variation in its pharmacokinetic features in cats compared to other animal species. Further studies are needed to evaluate whether TAP would be suitable for use in cats that are experiencing moderate to severe pain, but are sensitive to the adverse effects of commonly prescribed opioids." @default.
- W2912493033 created "2019-02-21" @default.
- W2912493033 creator A5012062096 @default.
- W2912493033 creator A5023143306 @default.
- W2912493033 creator A5066925125 @default.
- W2912493033 creator A5086576607 @default.
- W2912493033 date "1995-10-01" @default.
- W2912493033 modified "2023-09-30" @default.
- W2912493033 title "PASTEURELLA MULTOCIDA INFECTION IN A DOG BITE WOUND" @default.
- W2912493033 cites W1973257318 @default.
- W2912493033 cites W2022623364 @default.
- W2912493033 cites W2036592109 @default.
- W2912493033 cites W2076489927 @default.
- W2912493033 cites W2119350282 @default.
- W2912493033 cites W2154348522 @default.
- W2912493033 doi "https://doi.org/10.1016/s0377-1237(17)30996-6" @default.
- W2912493033 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5530200" @default.
- W2912493033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28769318" @default.
- W2912493033 hasPublicationYear "1995" @default.
- W2912493033 type Work @default.
- W2912493033 sameAs 2912493033 @default.
- W2912493033 citedByCount "0" @default.
- W2912493033 crossrefType "journal-article" @default.
- W2912493033 hasAuthorship W2912493033A5012062096 @default.
- W2912493033 hasAuthorship W2912493033A5023143306 @default.
- W2912493033 hasAuthorship W2912493033A5066925125 @default.
- W2912493033 hasAuthorship W2912493033A5086576607 @default.
- W2912493033 hasBestOaLocation W29124930332 @default.
- W2912493033 hasConcept C112705442 @default.
- W2912493033 hasConcept C121332964 @default.
- W2912493033 hasConcept C125287762 @default.
- W2912493033 hasConcept C126322002 @default.
- W2912493033 hasConcept C142724271 @default.
- W2912493033 hasConcept C170493617 @default.
- W2912493033 hasConcept C181389837 @default.
- W2912493033 hasConcept C197934379 @default.
- W2912493033 hasConcept C204787440 @default.
- W2912493033 hasConcept C24890656 @default.
- W2912493033 hasConcept C27081682 @default.
- W2912493033 hasConcept C2776796551 @default.
- W2912493033 hasConcept C2777056448 @default.
- W2912493033 hasConcept C2779904517 @default.
- W2912493033 hasConcept C2780505013 @default.
- W2912493033 hasConcept C2781063702 @default.
- W2912493033 hasConcept C42219234 @default.
- W2912493033 hasConcept C523546767 @default.
- W2912493033 hasConcept C54355233 @default.
- W2912493033 hasConcept C71924100 @default.
- W2912493033 hasConcept C86803240 @default.
- W2912493033 hasConcept C87813604 @default.
- W2912493033 hasConcept C98274493 @default.
- W2912493033 hasConceptScore W2912493033C112705442 @default.
- W2912493033 hasConceptScore W2912493033C121332964 @default.
- W2912493033 hasConceptScore W2912493033C125287762 @default.
- W2912493033 hasConceptScore W2912493033C126322002 @default.
- W2912493033 hasConceptScore W2912493033C142724271 @default.
- W2912493033 hasConceptScore W2912493033C170493617 @default.
- W2912493033 hasConceptScore W2912493033C181389837 @default.
- W2912493033 hasConceptScore W2912493033C197934379 @default.
- W2912493033 hasConceptScore W2912493033C204787440 @default.
- W2912493033 hasConceptScore W2912493033C24890656 @default.
- W2912493033 hasConceptScore W2912493033C27081682 @default.
- W2912493033 hasConceptScore W2912493033C2776796551 @default.
- W2912493033 hasConceptScore W2912493033C2777056448 @default.
- W2912493033 hasConceptScore W2912493033C2779904517 @default.
- W2912493033 hasConceptScore W2912493033C2780505013 @default.
- W2912493033 hasConceptScore W2912493033C2781063702 @default.
- W2912493033 hasConceptScore W2912493033C42219234 @default.
- W2912493033 hasConceptScore W2912493033C523546767 @default.
- W2912493033 hasConceptScore W2912493033C54355233 @default.
- W2912493033 hasConceptScore W2912493033C71924100 @default.
- W2912493033 hasConceptScore W2912493033C86803240 @default.
- W2912493033 hasConceptScore W2912493033C87813604 @default.
- W2912493033 hasConceptScore W2912493033C98274493 @default.
- W2912493033 hasIssue "4" @default.
- W2912493033 hasLocation W29124930331 @default.
- W2912493033 hasLocation W29124930332 @default.
- W2912493033 hasLocation W29124930333 @default.
- W2912493033 hasLocation W29124930334 @default.
- W2912493033 hasOpenAccess W2912493033 @default.
- W2912493033 hasPrimaryLocation W29124930331 @default.
- W2912493033 hasRelatedWork W1984317973 @default.
- W2912493033 hasRelatedWork W2001333918 @default.
- W2912493033 hasRelatedWork W2020343058 @default.
- W2912493033 hasRelatedWork W2042287403 @default.
- W2912493033 hasRelatedWork W2112099731 @default.
- W2912493033 hasRelatedWork W2134252786 @default.
- W2912493033 hasRelatedWork W2168998760 @default.
- W2912493033 hasRelatedWork W2317627837 @default.
- W2912493033 hasRelatedWork W2414263157 @default.
- W2912493033 hasRelatedWork W2425576493 @default.
- W2912493033 hasVolume "51" @default.
- W2912493033 isParatext "false" @default.
- W2912493033 isRetracted "false" @default.
- W2912493033 magId "2912493033" @default.
- W2912493033 workType "article" @default.