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- W2912493162 abstract "Disturbance in redox homeostasis at high altitude due to hypobaric hypoxia has been implicated in several physiological as well as pathological consequences. A shift in the redox potential leads to modulation of key biological cascades which are intricately regulated by proteins. Enhanced oxidative protein modifications at high altitude trigger several protective responses such as the heat shock response or the unfolded protein response to restore the protein homeostasis thus counteracting the stress and promoting cell survival. Upregulation of heat shock response enhanced hypoxic tolerance and better survival under low oxygen tensions. Modulation of proteostasis by upregulation of heat shock proteins and concomitant protein quality control mechanisms play a very important role in differential tolerance or susceptibility to environmental hypoxia. Hence, the present work potentiate the use of proteostasis modulators either chemical or herbal which can be developed as therapeutic interventions for the treatment of a multitude of hypoxia related pathophysiologies." @default.
- W2912493162 created "2019-02-21" @default.
- W2912493162 creator A5030531796 @default.
- W2912493162 creator A5067057858 @default.
- W2912493162 date "2019-01-01" @default.
- W2912493162 modified "2023-09-25" @default.
- W2912493162 title "Upregulation of Cytoprotective Chaperones Mediate Better Tolerance to High Altitude" @default.
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