Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912495470> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W2912495470 abstract "Cognitive toxicity induced by cranial radiation is one of the most important limitations of radiation therapy and has a significant impact on brain tumor survivors' quality of life. This review comprehends an up to date of recent studies including complete neuropsychological battery and/or advanced neuroimaging techniques. These studies identified critical anatomical and/or functional brain areas related to radiation-induced brain injury, thus improving clinical and radiological diagnosis. Pathophysiological mechanisms underlying cognitive toxicity are complex and involve different cell lines and molecules. Although there is no currently therapeutic strategy that has a demonstrated efficacy, several studies including sparing of hippocampus or the use of memantine are quite promising. A better knowledge of the characteristics of cognitive toxicity induced by cranial radiation, will help us to identify patients who will benefit from treatment and also to examine new therapeutic targets in order to improve patients' quality of life.Neurotoxicidad cognitiva inducida por la radioterapia cerebral en adultos.La toxicidad cognitiva inducida por la radioterapia craneal es una de las limitaciones mas importantes del tratamiento radioterapico y con mas impacto sobre la calidad de vida de los largos supervivientes de tumores cerebrales. Esta revision incluye una actualizacion del diagnostico clinico y radiologico de la toxicidad radioinducida con la incorporacion de baterias neuropsicologicas y tecnicas avanzadas en neuroimagen. Ambas herramientas han permitido en los ultimos años no solo una mejor definicion de la disfuncion cognitiva, sino tambien la identificacion de los cambios anatomicos y funcionales asociados. La fisiopatologia subyacente implica diferentes estirpes celulares y vias de señalizacion molecular, y el mecanismo es multifactorial. Aunque no existe actualmente una estrategia terapeutica que haya demostrado una clara eficacia, varios estudios, incluyendo los que proponen respetar el hipocampo o el uso de la memantina, han resultado prometedores. Profundizar en el estudio de la toxicidad cognitiva inducida por la radioterapia permitira definir mejor los pacientes que se benefician de la radioterapia, asi como estudiar nuevas dianas terapeuticas para mejorar la calidad de vida de los pacientes con daño cerebral radioinducido." @default.
- W2912495470 created "2019-02-21" @default.
- W2912495470 creator A5018144464 @default.
- W2912495470 creator A5027361825 @default.
- W2912495470 date "2019-01-01" @default.
- W2912495470 modified "2023-09-23" @default.
- W2912495470 title "Neurotoxicidad cognitiva inducida por la radioterapia cerebral en adultos" @default.
- W2912495470 doi "https://doi.org/10.33588/rn.6804.2018492" @default.
- W2912495470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30741403" @default.
- W2912495470 hasPublicationYear "2019" @default.
- W2912495470 type Work @default.
- W2912495470 sameAs 2912495470 @default.
- W2912495470 citedByCount "1" @default.
- W2912495470 countsByYear W29124954702021 @default.
- W2912495470 crossrefType "journal-article" @default.
- W2912495470 hasAuthorship W2912495470A5018144464 @default.
- W2912495470 hasAuthorship W2912495470A5027361825 @default.
- W2912495470 hasConcept C118552586 @default.
- W2912495470 hasConcept C126322002 @default.
- W2912495470 hasConcept C138885662 @default.
- W2912495470 hasConcept C14216870 @default.
- W2912495470 hasConcept C15708023 @default.
- W2912495470 hasConcept C169900460 @default.
- W2912495470 hasConcept C2779134260 @default.
- W2912495470 hasConcept C2779483572 @default.
- W2912495470 hasConcept C2779484449 @default.
- W2912495470 hasConcept C2984915365 @default.
- W2912495470 hasConcept C71924100 @default.
- W2912495470 hasConceptScore W2912495470C118552586 @default.
- W2912495470 hasConceptScore W2912495470C126322002 @default.
- W2912495470 hasConceptScore W2912495470C138885662 @default.
- W2912495470 hasConceptScore W2912495470C14216870 @default.
- W2912495470 hasConceptScore W2912495470C15708023 @default.
- W2912495470 hasConceptScore W2912495470C169900460 @default.
- W2912495470 hasConceptScore W2912495470C2779134260 @default.
- W2912495470 hasConceptScore W2912495470C2779483572 @default.
- W2912495470 hasConceptScore W2912495470C2779484449 @default.
- W2912495470 hasConceptScore W2912495470C2984915365 @default.
- W2912495470 hasConceptScore W2912495470C71924100 @default.
- W2912495470 hasLocation W29124954701 @default.
- W2912495470 hasLocation W29124954702 @default.
- W2912495470 hasOpenAccess W2912495470 @default.
- W2912495470 hasPrimaryLocation W29124954701 @default.
- W2912495470 hasRelatedWork W1986439510 @default.
- W2912495470 hasRelatedWork W2009699244 @default.
- W2912495470 hasRelatedWork W2068434728 @default.
- W2912495470 hasRelatedWork W2136684557 @default.
- W2912495470 hasRelatedWork W2324078469 @default.
- W2912495470 hasRelatedWork W2472523844 @default.
- W2912495470 hasRelatedWork W2896448091 @default.
- W2912495470 hasRelatedWork W2918615092 @default.
- W2912495470 hasRelatedWork W3109303516 @default.
- W2912495470 hasRelatedWork W3131437218 @default.
- W2912495470 isParatext "false" @default.
- W2912495470 isRetracted "false" @default.
- W2912495470 magId "2912495470" @default.
- W2912495470 workType "article" @default.