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• W2912495905 endingPage "488" @default.
• W2912495905 startingPage "476" @default.
• W2912495905 abstract "A large number of elements in nature can be classified as metals. Many of these, such as copper, iron, and zinc, are important to life, while others, for example, mercury, lead, and cadmium, have adverse effects on the biological system and may be referred to as toxic metals. The most significant neurotoxic metals are mercury, lead, arsenic, cadmium, aluminum, and manganese. Some metals exist as organometals, such as methylmercury, alkyl leads, triethyltin, and trimethyltin, which are also potent neurotoxicants. A notable problem in studying the neurotoxicity of metals is that some metals that are essential elements for normal cellular function are toxic at high concentrations or when encountered in their free forms unbound to typical cellular substrates. Understanding mechanisms by which endogenous and xenobiotic metals perturb normal cellular function is central to identifying and predicting neurotoxic outcomes of exposure. The intent of this chapter is therefore to provide a basic understanding of the source, routes of exposure, and mechanism of action for the major classes of metals with known neurotoxic liability, rather than to provide an exhaustive compendium of all reported neurotoxic effects. There are many excellent published reviews for the metals discussed, and the reader is encouraged to consult these and the references cited for more detailed information." @default.
• W2912495905 created "2019-02-21" @default.
• W2912495905 creator A5028190216 @default.
• W2912495905 date "2018-01-01" @default.
• W2912495905 modified "2023-09-25" @default.
• W2912495905 title "Neurotoxicology of Metals" @default.
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