FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912495984> ?p ?o ?g. }

• W2912495984 endingPage "578" @default.
• W2912495984 startingPage "572" @default.
• W2912495984 abstract "Objective. Multidrug resistance (MDR) transporters may be used as biomarkers to monitor disease progression in RA and as a predictive tool to establish responsiveness to biological therapy. In this multicenter clinical trial, we aimed to assess the predictive value of activity measurement of transporters MDR1, MD resistance protein (MRP)1, and breast cancer resistance protein (BCRP) for biological therapeutic response in RA before the initiation of biological therapy as well as 4 to 6 and 12 weeks after. Methods. Peripheral blood samples were collected from 27 responders and 12 nonresponders to biological disease-modifying antirheumatic drugs (bDMARD) at the indicated timepoints as well as from 35 healthy controls. MDR activity factor (MAF) of MDR1, MRP1, and BCRP was measured in CD3+ and CD19+ cells using the Solvo MDQ Kit and cell surface staining by flow cytometry following peripheral blood mononuclear cells isolation. Results. At the start of therapy, MAFC (composite MAF of MRP1 and MDR1) and MAFMDR values, and at 4 to 6 weeks of treatment, MAFC, MAFMRP, and MAFMDR values of CD3 cells were higher in nonresponders compared to responders. Receiver-operation characteristic curve analysis revealed that RA patients with MAFC values above 21.3 in CD3 cells at the start of bDMARD therapy are likely to be nonresponders. At 4 to 6 weeks of treatment, these also predict unfavorable response: MAFC values above 20.3, MAFMRP values above 6.0, and MAFMDR values above 13.9 in CD3 cells. Conclusion. Our results indicate that the determination of MAFC values in CD3 cells of patients with RA may be of predictive value prior to the initiation of biological therapy, to establish whether the patient will demonstrate sufficient therapeutic response." @default.
• W2912495984 created "2019-02-21" @default.
• W2912495984 creator A5003301967 @default.
• W2912495984 creator A5011103966 @default.
• W2912495984 creator A5012926852 @default.
• W2912495984 creator A5019242910 @default.
• W2912495984 creator A5020937342 @default.
• W2912495984 creator A5022474029 @default.
• W2912495984 creator A5029099340 @default.
• W2912495984 creator A5029915112 @default.
• W2912495984 creator A5029969068 @default.
• W2912495984 creator A5058675581 @default.
• W2912495984 creator A5063721274 @default.
• W2912495984 creator A5072517126 @default.
• W2912495984 date "2019-02-01" @default.
• W2912495984 modified "2023-10-17" @default.
• W2912495984 title "Peripheral Lymphocyte Multidrug Resistance Activity as a Predictive Tool of Biological Therapeutic Response in Rheumatoid Arthritis" @default.
• W2912495984 cites W1818425958 @default.
• W2912495984 cites W1977239175 @default.
• W2912495984 cites W1982496443 @default.
• W2912495984 cites W2033911404 @default.
• W2912495984 cites W2055552847 @default.
• W2912495984 cites W2108527751 @default.
• W2912495984 cites W2120393706 @default.
• W2912495984 cites W2138285200 @default.
• W2912495984 cites W2178335951 @default.
• W2912495984 cites W2214034182 @default.
• W2912495984 cites W2401583555 @default.
• W2912495984 cites W2796552195 @default.
• W2912495984 cites W2898149166 @default.
• W2912495984 cites W4295125684 @default.
• W2912495984 doi "https://doi.org/10.3899/jrheum.180793" @default.
• W2912495984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30709954" @default.
• W2912495984 hasPublicationYear "2019" @default.
• W2912495984 type Work @default.
• W2912495984 sameAs 2912495984 @default.
• W2912495984 citedByCount "2" @default.
• W2912495984 countsByYear W29124959842019 @default.
• W2912495984 countsByYear W29124959842020 @default.
• W2912495984 crossrefType "journal-article" @default.
• W2912495984 hasAuthorship W2912495984A5003301967 @default.
• W2912495984 hasAuthorship W2912495984A5011103966 @default.
• W2912495984 hasAuthorship W2912495984A5012926852 @default.
• W2912495984 hasAuthorship W2912495984A5019242910 @default.
• W2912495984 hasAuthorship W2912495984A5020937342 @default.
• W2912495984 hasAuthorship W2912495984A5022474029 @default.
• W2912495984 hasAuthorship W2912495984A5029099340 @default.
• W2912495984 hasAuthorship W2912495984A5029915112 @default.
• W2912495984 hasAuthorship W2912495984A5029969068 @default.
• W2912495984 hasAuthorship W2912495984A5058675581 @default.
• W2912495984 hasAuthorship W2912495984A5063721274 @default.
• W2912495984 hasAuthorship W2912495984A5072517126 @default.
• W2912495984 hasBestOaLocation W29124959841 @default.
• W2912495984 hasConcept C114684123 @default.
• W2912495984 hasConcept C126322002 @default.
• W2912495984 hasConcept C137061746 @default.
• W2912495984 hasConcept C143998085 @default.
• W2912495984 hasConcept C167672396 @default.
• W2912495984 hasConcept C202751555 @default.
• W2912495984 hasConcept C203014093 @default.
• W2912495984 hasConcept C2777575956 @default.
• W2912495984 hasConcept C2777761686 @default.
• W2912495984 hasConcept C2778957590 @default.
• W2912495984 hasConcept C553184892 @default.
• W2912495984 hasConcept C55493867 @default.
• W2912495984 hasConcept C71924100 @default.
• W2912495984 hasConcept C86803240 @default.
• W2912495984 hasConcept C8891405 @default.
• W2912495984 hasConcept C98274493 @default.
• W2912495984 hasConceptScore W2912495984C114684123 @default.
• W2912495984 hasConceptScore W2912495984C126322002 @default.
• W2912495984 hasConceptScore W2912495984C137061746 @default.
• W2912495984 hasConceptScore W2912495984C143998085 @default.
• W2912495984 hasConceptScore W2912495984C167672396 @default.
• W2912495984 hasConceptScore W2912495984C202751555 @default.
• W2912495984 hasConceptScore W2912495984C203014093 @default.
• W2912495984 hasConceptScore W2912495984C2777575956 @default.
• W2912495984 hasConceptScore W2912495984C2777761686 @default.
• W2912495984 hasConceptScore W2912495984C2778957590 @default.
• W2912495984 hasConceptScore W2912495984C553184892 @default.
• W2912495984 hasConceptScore W2912495984C55493867 @default.
• W2912495984 hasConceptScore W2912495984C71924100 @default.
• W2912495984 hasConceptScore W2912495984C86803240 @default.
• W2912495984 hasConceptScore W2912495984C8891405 @default.
• W2912495984 hasConceptScore W2912495984C98274493 @default.
• W2912495984 hasIssue "6" @default.
• W2912495984 hasLocation W29124959841 @default.
• W2912495984 hasLocation W29124959842 @default.
• W2912495984 hasOpenAccess W2912495984 @default.
• W2912495984 hasPrimaryLocation W29124959841 @default.
• W2912495984 hasRelatedWork W1517610527 @default.
• W2912495984 hasRelatedWork W2056493880 @default.
• W2912495984 hasRelatedWork W2139188664 @default.
• W2912495984 hasRelatedWork W2380610400 @default.
• W2912495984 hasRelatedWork W2392106974 @default.
• W2912495984 hasRelatedWork W2410768169 @default.
• W2912495984 hasRelatedWork W2461543913 @default.
• W2912495984 hasRelatedWork W2519088134 @default.

• next