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• W2912496685 abstract "Introduction: Intestinal resection resulting in short bowel syndrome (SBS) can lead to intestinal failure (SBS-IF). SBS-IF arises from different etiologies, including vascular catastrophes and inflammatory bowel disease, resulting in a heterogeneous population. This post hoc analysis reports baseline characteristics and clinical response to teduglutide (TED) in patients based on residual bowel anatomy. Methods: STEPS (NCT00798967; EudraCT 2008-006193-15) was a 24-week, placebo-controlled study of TED 0.05 mg/kg/day in patients with SBS-IF. Three groups were evaluated: Group 1 (no colon/stoma present/no colon-in-continuity), Group 2 (≥50% colon/no stoma/colon-in-continuity), and Group 3 (other bowel anatomies). Clinical response was defined as ≥20% reduction from baseline in weekly parenteral support (PS) volume at Weeks 20-24. Data presented as mean (SD). Results: The predominant diagnosis was Crohn's disease in Group 1 and vascular complications in Group 2 (Table). Patients in Group 1 required the highest baseline PS volumes compared with Group 2 or Group 3. TED-induced PS volume reduction (change in L/week) took longer to be realized in Group 2 (Week 12: -0.9 [1.2]; Week 24: -2.5 [2.1]) compared with Group 1 (Week 12: -5.5 [3.8]; Week 24: -6.4 [4.5]) or Group 3 (Week 12: -2.7 [1.2]; Week 24: -5.1 [3.7]). Response rates were higher with TED versus placebo in all groups, but the difference was significant only in Group 1 (76% vs 19%, P=0.001; Group 2: 56% vs 40%, P=0.36; Group 3: 57% vs 29%, P=0.33). Adverse events were reported by 94%, 72%, and 86% of patients receiving TED in Groups 1, 2, and 3, respectively.Table: Table. Baseline Patient CharacteristicsConclusion: Patients with SBS-IF in Group 1 had the highest baseline PS volume needs and responded most and fastest to TED with PS volume reductions compared with patients in Group 2 or Group 3." @default.
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• W2912496685 date "2017-10-01" @default.
• W2912496685 modified "2023-10-13" @default.
• W2912496685 title "Results of a Post hoc Analysis of Baseline Characteristics and Clinical Response to Teduglutide in Patients With Short Bowel Syndrome Based on Residual Bowel Anatomy" @default.
• W2912496685 doi "https://doi.org/10.14309/00000434-201710001-01184" @default.
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